Exploring latent clusters in pediatric OCD based on symptoms, severity, age, gender, and comorbidity.

Given diverse symptom expression and high rates of comorbid conditions, the present study explored underlying commonalities among OCD-affected children and adolescents to better conceptualize disorder presentation and associated features. Data from 830 OCD-affected participants presenting to OCD spe...

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Published in:European Child & Adolescent Psychiatry Vol. 33; no. 11; pp. 3899 - 3913
Main Authors: Smárason, Orri, Selles, Robert R., Højgaard, Davíð R. M. A., Best, John R., Melin, Karin, Ivarsson, Tord, Thomsen, Per Hove, Weidle, Bernhard, McBride, Nicole Michelle, Storch, Eric A., Geller, Daniel, Wilhelm, Sabine, Farrell, Lara J., Waters, Allison M., Mathieu, Sharna, Soreni, Noam, Stewart, S. Evelyn, Skarphedinsson, Gudmundur
Format: research tables/charts Journal Article
Published: Springer Nature Nov2024
Online Access:View this record in EBSCOhost
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      dt: Nov2024
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        atl: Exploring latent clusters in pediatric OCD based on symptoms, severity, age, gender, and comorbidity.
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          Smárason, Orri
          Selles, Robert R.
          Højgaard, Davíð R. M. A.
          Best, John R.
          Melin, Karin
          Ivarsson, Tord
          Thomsen, Per Hove
          Weidle, Bernhard
          McBride, Nicole Michelle
          Storch, Eric A.
          Geller, Daniel
          Wilhelm, Sabine
          Farrell, Lara J.
          Waters, Allison M.
          Mathieu, Sharna
          Soreni, Noam
          Stewart, S. Evelyn
          Skarphedinsson, Gudmundur
        affil: https://ror.org/01db6h964 Faculty of Psychology, University of Iceland, Reykjavik, Iceland
      sug:
        subj:
          Obsessive-Compulsive Disorder Risk Factors
          Obsessive-Compulsive Disorder Risk Factors
          Obsessive-Compulsive Disorder Symptoms
          Severity of Illness Evaluation
          Age Factors Evaluation
          Sex Factors Evaluation
          Comorbidity Evaluation
          Risk Assessment
          Human
          Checklists
          Child
          Adolescence
          Male
          Female
          Child: 6-12 years
          Adolescent: 13-18 years
          Male
          Female
      ab: Given diverse symptom expression and high rates of comorbid conditions, the present study explored underlying commonalities among OCD-affected children and adolescents to better conceptualize disorder presentation and associated features. Data from 830 OCD-affected participants presenting to OCD specialty centers was aggregated. Dependent mixture modeling was used to examine latent clusters based on their age- and gender adjusted symptom severity (as measured by the Children's Yale-Brown Obsessive-Compulsive Scale; CY-BOCS), symptom type (as measured by factor scores calculated from the CY-BOCS symptom checklist), and comorbid diagnoses (as assessed via diagnostic interviews). Fit statistics favored a four-cluster model with groups distinguished primarily by symptom expression and comorbidity type. Fit indices for 3–7 cluster models were only marginally different and characteristics of the clusters remained largely stable between solutions with small clusters of distinct presentations added in more complex models. Rather than identifying a single classification system, the findings support the utility of integrating dimensional, developmental, and transdiagnostic information in the conceptualization of OCD-affected children and adolescents. Identified clusters point to the centrality of contamination concerns to OCD, relationships between broader symptom expression and higher levels of comorbidity, and the potential for complex/neurodevelopmental presentations.
      pubtype: Academic Journal
      doctype:
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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