Aortic pulse wave velocity predicts cardiovascular mortality among middle-aged metabolic syndrome subjects without overt cardiovascular disease.
Background: The objective of this cohort study was to assess the predictive value of main arterial markers for cardiovascular death in middle-aged subjects with metabolic syndrome (MetS). Methods: This prospective longitudinal study analyzed data from 5829 metabolic syndrome subjects without overt c...
| Publicado en: | Nutrition & Metabolism Vol. 21; no. 1; pp. 1 - 11 |
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| Autores principales: | , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
BioMed Central
12/2/2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=181254233&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 181254233 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 17437075 1CYX jtl: Nutrition & Metabolism issn: 17437075 maglogo: N pubinfo: dt: 12/2/2024 vid: 21 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 181254233 181254233 181254233 10.1186/s12986-024-00875-z 181254233 ppf: 1 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Aortic pulse wave velocity predicts cardiovascular mortality among middle-aged metabolic syndrome subjects without overt cardiovascular disease. aug: au: Jucevičienė, Agnė Puronaitė, Roma Badarienė, Jolita Ryliškytė, Ligita affil: https://ror.org/03nadee84 Clinic of Cardiovascular Diseases, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, M. K. Čiurlionio str. 21, LT-03101, Vilnius, Lithuania sug: subj: Metabolic Syndrome X Mortality Cardiovascular Diseases Mortality Mortality Risk Factors Risk Assessment Aorta Pulse Wave Velocity Predictive Value of Tests Human Male Female Adult Middle Age Prospective Studies Carotid Intima-Media Thickness Carotid Arteries Blood Flow Velocity Cardio Ankle Vascular Index Heart Rate Cardiovascular System Physiology Cox Proportional Hazards Model Regression Descriptive Statistics Confidence Intervals Survival Analysis C-Reactive Protein Smoking Sex Factors Clinical Assessment Tools Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Background: The objective of this cohort study was to assess the predictive value of main arterial markers for cardiovascular death in middle-aged subjects with metabolic syndrome (MetS). Methods: This prospective longitudinal study analyzed data from 5829 metabolic syndrome subjects without overt cardiovascular disease aged between 40 and 64 years and enrolled in the Lithuanian High Cardiovascular Risk primary prevention program. Initial assessment comprised the evaluation of aortic pulse wave velocity (aPWV), carotid intima-media thickness (cIMT), carotid stiffness index, cardio-ankle vascular index (CAVI), ankle-brachial index (ABI), aortic augmentation index adjusted for a heart rate of 75 bpm (AIXHR75), and endothelium-dependent flow-mediated dilatation (FMD). Results: During the mean follow-up period of 6.35 ± 2.99 years, 170 subjects (2.9%) had died, with 41 out of these deaths (24.1%) related to cardiovascular causes. Cox proportional hazard regression analysis revealed associations between cardiovascular deaths and increases in aPWV (HR 1.34, 95% CI 1.14–1.58, p < 0.001), CAVI (HR 1.28, 95% CI 1.09–1.50, p = 0.002), and cIMT (HR 1.004, 95% CI 1.001–1.006, p = 0.003), as well as a decrease in ABI (HR 0.020, 95% CI 0.001–0.359, p = 0.008). However, after adjustment for age and gender, only aPWV remained a statistically significant predictor. Common survival tree analysis foregrounded the predictive significance of C-reactive protein (CRP), as the primary variable associated with an increased risk of cardiovascular death, followed by aPWV and smoking as secondary and tertiary variables. The analysis also demonstrated sex-related differences: in women, the primary predictive variable was aPWV, whereas in men, CRP was identified as the primary variable, followed by CAVI and cIMT. Conclusions: The findings of this study suggest that, among the markers of subclinical arterial damage, an increase in both aPWV and CAVI has a statistically significant predictive value for cardiovascular mortality in the middle-aged subjects with MetS. However, only aPWV demonstrated predictive value that was independent of age and gender. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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