Medicina personalizada.

Precision medicine is a term that has become very popular in recent times, which explains that each individual has different characteristics at molecular, physiological, epigenetic and behavioral level. Therefore, every patient should receive interventions that are adaptable to either one. DNA conta...

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Publicado en:Medicina Interna de México Vol. 40; no. 10; pp. 657 - 663
Autores principales: Cerón Luna, Sebastián, Martínez Sánchez, Lina María, Senior Betancur, Pablo Andrés
Formato: Artículo
Publicado: Colegio de Medicina Interna de Mexico nov2024
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Acceso en línea:Ver este registro en EBSCOhost
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          Martínez Sánchez, Lina María
          Senior Betancur, Pablo Andrés
        affil: Bacterióloga, especialista en Hematología. Magister en Educación. Escuela de Ciencias de la Salud, Facultad de Medicina, Universidad Pontificia Bolivariana, sede Robledo, Medellín, Colombia.
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        Patient participation
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        Clinical importance
        Epigenomics
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        Molecular targeted therapy
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        Precision medicine is a term that has become very popular in recent times, which explains that each individual has different characteristics at molecular, physiological, epigenetic and behavioral level. Therefore, every patient should receive interventions that are adaptable to either one. DNA contains genes that are part of the genetic code, which oversees synthesizing protein. To study this process, five sciences were created: proteomics, transcriptomic, epigenomic, metabolomic and pharmacogenomics. Through these techniques, modern medicine is evolving, trying to pursue adjusted therapies, less exposure to ineffective or toxic medication, greater adherence to the treatment and increased patient participation in their recovery process. Some illnesses that could be treated by precision medicine are neoplastic processes, autoimmune and cardiovascular diseases. However, to accomplish these precise treatments it is required infrastructure, trained professional team, economic resources in healthcare and other considerations that could obstruct the applicability of this new medical practice.
        La medicina de precisión es un término que se ha vuelto muy popular recientemente, que se refiere a que cada individuo tiene diferentes características moleculares, fisiológicas, epigenéticas y de comportamiento, por lo que deben otorgarse intervenciones adaptables a cada persona. El ADN contiene genes que forman parte del código genético que, a su vez, se encargan de sintetizar proteínas. Se han desarrollado cinco ciencias con el fin de estudiarlo: proteómica, transcriptómica, epigenómica, metabolómica y farmacogenómica. Por medio de estos estudios del material genético se buscan tratamientos ajustados, menos exposición a medicaciones poco eficaces o tóxicas, mayor apego al tratamiento y aumento de la participación del paciente. Entre las enfermedades que se han descrito están los procesos neoplásicos y las enfermedades autoinmunitarias y cardiovasculares. Sin embargo, para ejecutar una medicina de precisión acorde se requiere infraestructura, equipo profesional capacitado, recursos económicos en salud, entre otras consideraciones que pueden dificultar la aplicabilidad de esta práctica médica.
      pubtype: Academic Journal
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      src: R
    language: Spanish
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