Adjunctive hyperbaric oxygen therapy and negative pressure wound therapy for hard-to-heal wounds: a systematic review and meta-analysis.
Objective: Negative pressure wound therapy (NPWT) and hyperbaric oxygen therapy (HBOT) have been widely used in the treatment of hard-to-heal (chronic) wounds, but there is still a lack of sufficient evidence for their combined use for the treatment of hard-to-heal wounds. This systematic review aim...
| Published in: | Journal of Wound Care Vol. 33; no. 12; pp. 950 - 958 |
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| Main Authors: | , , , , , , , |
| Format: | research systematic review tables/charts Journal Article |
| Published: |
Mark Allen Holdings Limited
Dec2024
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=181416732&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 181416732 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09690700 H3U jtl: Journal of Wound Care issn: 09690700 maglogo: N pubinfo: dt: Dec2024 vid: 33 iid: 12 pid: 11383 pub: Mark Allen Holdings Limited artinfo: ui: 181416732 181416732 181416732 10.12968/jowc.2022.0213 181416732 ppf: 950 ppct: 8 formats: tig: atl: Adjunctive hyperbaric oxygen therapy and negative pressure wound therapy for hard-to-heal wounds: a systematic review and meta-analysis. aug: au: Yang, Liehao Kong, Jiao Xing, Yunlong Pan, Lingfeng Li, Caihong Wu, Zhuoxia Li, Mingxi Zhang, Lianbo affil: Department of Plastic Surgery, China-Japan Union Hospital of Jilin University, Changchun City, Jilin Province, China sug: subj: Negative Pressure Wound Therapy Hyperbaric Oxygenation Wounds and Injuries Therapy Wound Healing Patient Safety Human Systematic Review Meta Analysis Embase PubMed Odds Ratio Confidence Intervals Descriptive Statistics Length of Stay Checklists Scales ab: Objective: Negative pressure wound therapy (NPWT) and hyperbaric oxygen therapy (HBOT) have been widely used in the treatment of hard-to-heal (chronic) wounds, but there is still a lack of sufficient evidence for their combined use for the treatment of hard-to-heal wounds. This systematic review aimed to identify the clinical efficacy and safety of adding adjunctive HBOT to NPWT for hard-to-heal wounds. Method: Embase, PubMed, Cochrane Library, Web of Science, China National Knowledge Infrastructure and Wanfang were searched from the establishment of the database to March 2022. The literature was screened according to the inclusion criteria and exclusion criteria. We assessed the quality of each included study with the Cochrane Collaboration Risk of Bias tool and Newcastle–Ottawa Scale. A meta-analysis was performed using R programming software version 4.1.0 (R Project for Statistical Computing, US). The PRISMA 2020 guidelines were used to report data from systematic reviews and meta-analysis. Results: A total of 15 studies were identified, including nine randomised clinical controlled trials and six retrospective studies. Meta-analysis results showed that NPWT combined with HBOT had better outcomes compared with the NPWT alone with regards to: wound healing rate (odds ratio (OR)=6.77; 95% confidence interval (Cl): 3.53–12.98; p<0.0001); bacterial positive rate of wound (OR=0.16; 95% CI: 0.05–0.55; p=0.0037); wound healing time (mean difference (MD)= –3.86; 95% Cl: –5.18 – –2.53; p<0.0001); wound area (standardised mean difference (SMD)=1.50; 95% Cl: 0.35–2.65; p=0.0104); hospitalisation time (MD= –3.14; 95% Cl: –4.93 – –1.36; p=0.005); and hospitalisation cost (OR= –202.64; 95% Cl: –404.53 – –0.75; p=0.0492). There was no significant difference in pain score (MD= –0.43; 95% Cl: –1.15–0.30; p=0.25). Conclusion: The findings of this study demonstrated that adjunctive HBOT with NPWT is safe and effective in the treatment of hard-to-heal wounds. However, these findings should be interpreted with great caution given the limitations of the studies included. pubtype: Academic Journal doctype: meta analysis research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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