Altered Cytokine Production in Patients with Helicobacter pylori Infection.
Background: Helicobacter pylori is a gram-negative pathogen. The infection caused by this pathogen may result in gastritis and can increase the risk of gastric cancer. This study investigated the relationship between H. pylori infection as the main risk factor for gastritis and changes in serum infl...
| Publicado en: | Middle East Journal of Digestive Diseases Vol. 16; no. 4; pp. 235 - 242 |
|---|---|
| Autores principales: | , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Iranian Association of Gastroenterology & Hepatology
Oct2024
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=181466886&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 181466886 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20085230 BG4K jtl: Middle East Journal of Digestive Diseases issn: 20085230 maglogo: N pubinfo: dt: Oct2024 vid: 16 iid: 4 pid: 70725 pub: Iranian Association of Gastroenterology & Hepatology artinfo: ui: 181466886 181466886 181466886 10.34172/mejdd.2024.398 181466886 ppf: 235 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Altered Cytokine Production in Patients with Helicobacter pylori Infection. aug: au: Mahmoodzadeh, Abdollah Safikhani Moazamian, Elham Shamsdin, Seyedeh Azra Kaydani, Gholam Abas affil: Department of Microbiology, College of Sciences, Agriculture and Modern Technology, Shiraz Branch, Islamic Azad University, Shiraz, Iran sug: subj: Helicobacter Infections Complications Gastritis Risk Factors Cytokines Blood Inflammation Blood Risk Assessment Human Iran Male Female Adult Middle Age Blood Specimen Collection Abdominal Pain Immunohistochemistry Flow Cytometry Methods Interleukins Blood Tumor Necrosis Factor Interferon-gamma Release Tests Serum Globulins Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Background: Helicobacter pylori is a gram-negative pathogen. The infection caused by this pathogen may result in gastritis and can increase the risk of gastric cancer. This study investigated the relationship between H. pylori infection as the main risk factor for gastritis and changes in serum inflammatory cytokine levels. Methods: Blood samples from 85 patients with stomach pain, including 46 H. pylori-positive (Hp+) and 39 H. pylori-negative (Hp-) cases, were collected and referred to a gastroenterologist. After isolation and identification of H. pylori, the severity of gastritis was determined for each patient based on the histopathological findings. Finally, the serum levels of cytokines were measured using the multiplex kit and flow cytometry methods. Results: There were significant differences in the levels of interleukin-2 (IL-2), IL-4, IL-17A, IL-17F, IL-22, tumor necrosis factoralpha (TNF-α), and interferon-gamma (IFN-γ) between the Hp- and the Hp+ specimens (P ≤ 0.05). The levels of IL-2, IL-17A, IL-17F, IL-22, TNF-α, and IFN-γ were significantly higher in patients with mild and moderate gastritis than Hp- group (P ≤ 0.05). In addition, IL-4 significantly increased in patients with moderate gastritis compared with Hp- individuals (P = 0.008). Conclusion: Among the inflammatory cytokines evaluated in this study, IL-17A, IL-17F, and IL-22 may play a crucial role in developing moderate gastritis in infected patients with H. pylori. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|