Serosurveillance of Post vaccination SARS-CoV-2 antibodies in Covishield and Covaxin Vaccinated Subjects.
Background: Whole virion (attenuated) vaccine (Covaxin) and m-RNA of whole Spike protein (Covishield) were used as emergency measures in SARS-CoV-2 infection. Aim & Objective: To evaluate the antigenicity of both vaccines by measuring the quantum of antibodies. Methods and Material: Periodic antigen...
| Publicado en: | Indian Journal of Community Health Vol. 36; no. 5; pp. 661 - 674 |
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| Autores principales: | , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Indian Journal of Community Health
Oct2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=181466906&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 181466906 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09717587 DURZ jtl: Indian Journal of Community Health issn: 09717587 maglogo: N pubinfo: dt: Oct2024 vid: 36 iid: 5 pid: 24450 pub: Indian Journal of Community Health artinfo: ui: 181466906 181466906 181466906 10.47203/IJCH.2024.v36i05.007 181466906 ppf: 661 ppct: 13 formats: tig: atl: Serosurveillance of Post vaccination SARS-CoV-2 antibodies in Covishield and Covaxin Vaccinated Subjects. aug: au: Barthwal, Shilpa Angel, Bennet Angel, Annette Joshi, Vinod Praveen, Uppu Khaneja, Poorna Buvvaji, Shareef Mohammed Joshi, Ramesh affil: Centre of Excellence in Virology & Immunology, Sharda University, Greater Noida, Uttar Pradesh sug: subj: COVID-19 Prevention and Control COVID-19 Vaccines Therapeutic Use Immunization Antigens Blood COVID-19 Vaccines Immunology Antibodies, Viral Blood Vaccine Efficacy Human Male Female Adolescence Adult Middle Age Aged Immunoglobulins India Data Analysis Software Inferential Statistics Chi Square Test Fisher's Exact Test Descriptive Statistics Funding Source Adolescent: 13-18 years Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Background: Whole virion (attenuated) vaccine (Covaxin) and m-RNA of whole Spike protein (Covishield) were used as emergency measures in SARS-CoV-2 infection. Aim & Objective: To evaluate the antigenicity of both vaccines by measuring the quantum of antibodies. Methods and Material: Periodic antigenicity of both the vaccines post-vaccination i.e. after 5-6 and 11-12 months was undertaken in two categories; those who were not infected and vaccinated and secondly infected and vaccinated and got re-infected (after vaccination). Results: Both the categories of patients showed similar quantum of IgA/IgG/ IgM and Neutralizing antibodies generated by Covaxin. In subjects, vaccinated by Covishield, the recipients of single dose of vaccine showed higher titre of antibodies than double dose vaccinated. Less antigenicity of Covishield vaccine in infected vaccinated was seen compared to un-infected vaccinated subjects. Conclusions: Paper reports antigenic strength of both the vaccines during 5-6 and 11-12 months' post-vaccination and also the important point that antibodies titre was higher among cohort of single vaccinated as compared to those who received two doses of vaccines. The paper further sensitises the issue that both the vaccines were developed on the Wuhan strain whereas the virus has mutated twice, generating two new subsequent strains namely Delta and Omicron. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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