An Artificial Intelligent System for Prostate Cancer Diagnosis in Whole Slide Images.
In recent years a significant demand to develop computer-assisted diagnostic tools to assess prostate cancer using whole slide images has been observed. In this study we develop and validate a machine learning system for cancer assessment, inclusive of detection of perineural invasion and measuremen...
| Publicado en: | Journal of Medical Systems Vol. 48; no. 1; pp. 1 - 17 |
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| Autores principales: | , , , , , , , , , , , , , , , |
| Formato: | equations & formulas pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
10/28/2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=181643156&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 181643156 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01485598 4N0 jtl: Journal of Medical Systems issn: 01485598 maglogo: N pubinfo: dt: 10/28/2024 vid: 48 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 181643156 181643156 181643156 10.1007/s10916-024-02118-3 181643156 ppf: 1 ppct: 16 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: An Artificial Intelligent System for Prostate Cancer Diagnosis in Whole Slide Images. aug: au: Saha, Sajib Vignarajan, Janardhan Flesch, Adam Jelinko, Patrik Gorog, Petra Szep, Eniko Toth, Csaba Gombas, Peter Schvarcz, Tibor Mihaly, Orsolya Kapin, Marianna Zub, Alexandra Kuthi, Levente Tiszlavicz, Laszlo Glasz, Tibor Frost, Shaun affil: https://ror.org/04ywhbc61 Australian e-Health Research Centre, CSIRO, Kensington, Australia sug: subj: Prostatic Neoplasms Pathology Prostatic Neoplasms Diagnosis Convolutional Neural Networks Methods Diagnosis, Computer Assisted Methods Image Interpretation, Computer Assisted Image Processing, Computer Assisted Human Male Artificial Intelligence Deep Learning Machine Learning Algorithms Sensitivity and Specificity ROC Curve Descriptive Statistics Male ab: In recent years a significant demand to develop computer-assisted diagnostic tools to assess prostate cancer using whole slide images has been observed. In this study we develop and validate a machine learning system for cancer assessment, inclusive of detection of perineural invasion and measurement of cancer portion to meet clinical reporting needs. The system analyses the whole slide image in three consecutive stages: tissue detection, classification, and slide level analysis. The whole slide image is divided into smaller regions (patches). The tissue detection stage relies upon traditional machine learning to identify WSI patches containing tissue, which are then further assessed at the classification stage where deep learning algorithms are employed to detect and classify cancer tissue. At the slide level analysis stage, entire slide level information is generated by aggregating all the patch level information of the slide. A total of 2340 haematoxylin and eosin stained slides were used to train and validate the system. A medical team consisting of 11 board certified pathologists with prostatic pathology subspeciality competences working independently in 4 different medical centres performed the annotations. Pixel-level annotation based on an agreed set of 10 annotation terms, determined based on medical relevance and prevalence, was created by the team. The system achieved an accuracy of 99.53% in tissue detection, with sensitivity and specificity respectively of 99.78% and 99.12%. The system achieved an accuracy of 92.80% in classifying tissue terms, with sensitivity and specificity respectively 92.61% and 99.25%, when 5x magnification level was used. For 10x magnification, these values were respectively 91.04%, 90.49%, and 99.07%. For 20x magnification they were 84.71%, 83.95%, 90.13%. pubtype: Academic Journal doctype: equations & formulas pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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