Body mass index as a determinant of scar formation post‐AF ablation: Insights from DECAAF II.
Introduction: Obesity is implicated in adverse atrial remodeling and worse outcomes in patients with atrial fibrillation. The objective of this study is to assess the effect of body mass index (BMI) on ablation‐induced scar formation on late gadolinium enhancement cardiac magnetic resonance imaging...
| Publicado en: | Journal of Cardiovascular Electrophysiology Vol. 35; no. 12; pp. 2330 - 2342 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Dec2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=181701917&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 181701917 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10453873 GSB jtl: Journal of Cardiovascular Electrophysiology issn: 10453873 maglogo: Y pubinfo: dt: Dec2024 vid: 35 iid: 12 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 181701917 180067752 181701917 181701917 10.1111/jce.16448 181701917 ppf: 2330 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Body mass index as a determinant of scar formation post‐AF ablation: Insights from DECAAF II. aug: au: Bidaoui, Ghassan Tsakiris, Eli Younes, Hadi Feng, Han Assaf, Ala Chouman, Nour Bsoul, Mayana Polo, Francisco Tirado Jia, Yishi Liu, Yingshou Lim, Chanho Chamoun, Nadia Mekhael, Mario Noujaim, Charbel Pandey, Amitabh C. Rao, Swati Kreidieh, Omar Marrouche, Nassir F. Donnellan, Eoin affil: Tulane Research Innovation for Arrhythmia Discovery (TRIAD), Cardiac Electrophysiology, Tulane University School of Medicine, New Orleans Louisiana, , USA sug: subj: Body Mass Index Cicatrix Etiology Atrial Fibrillation Surgery Catheter Ablation Adverse Effects Magnetic Resonance Imaging Image Enhancement Human Treatment Outcomes Comorbidity Obesity Body Weight Descriptive Statistics Fibrosis Male Female Middle Age Aged Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Introduction: Obesity is implicated in adverse atrial remodeling and worse outcomes in patients with atrial fibrillation. The objective of this study is to assess the effect of body mass index (BMI) on ablation‐induced scar formation on late gadolinium enhancement cardiac magnetic resonance imaging (LGE‐CMR). Methods: We conducted an analysis of DECAAF II participants who underwent LGE‐CMR scans to measure scar formation 3 months after catheter ablation. Ablation parameters and lesion delivery were not dependent on BMI. The effect of BMI on ablation success was explored. Results: Our analyses included 811 patients. Comorbidities were more prevalent in obese patients. Baseline left atrial volume was higher in obese individuals, 118, 126, 135, 140, and 143 mm3 for normal weight, overweight, obese grade 1, 2, and 3, respectively (p <.001). BMI was associated with scar formation (R = −0.135, p <.001), with patients with Class 3 obesity having the lowest percentage of ablation‐induced scar, 11.1%, 10.3%, 9.5%, 8.8%, 6.8% by ascending BMI group. There was an inverse correlation between BMI and the amount of fibrosis covered by ablation scar, 24%, 23%, 21%, and 18% by ascending BMI group (p =.001). For the fibrosis‐guided ablation group, BMI was associated with residual fibrosis (R = 0.056, p =.005). Conclusion: Obese patients have lower ablation scar formation, covered fibrosis, and more residual fibrosis postablation compared to nonobese patients, regardless of ablation parameters including impedance drop. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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