Alterations in inhibitory neuron subtype-selective transcripts in the prefrontal cortex: comparisons across schizophrenia and mood disorders.
Background: In schizophrenia (SZ), impairments in cognitive functions, such as working memory, have been associated with alterations in certain types of inhibitory neurons that utilize the neurotransmitter γ -aminobutyric acid (GABA) in the dorsolateral prefrontal cortex (DLPFC). For example, GABA n...
| Publicado en: | Psychological Medicine Vol. 54; no. 14; pp. 3896 - 3906 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Cambridge University Press
Oct2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=181784348&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 181784348 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00332917 6Q3 jtl: Psychological Medicine issn: 00332917 maglogo: N pubinfo: dt: Oct2024 vid: 54 iid: 14 pid: 15979 pub: Cambridge University Press artinfo: ui: 181784348 181784348 181784348 10.1017/S0033291724002344 181784348 ppf: 3896 ppct: 10 formats: tig: atl: Alterations in inhibitory neuron subtype-selective transcripts in the prefrontal cortex: comparisons across schizophrenia and mood disorders. aug: au: Okuda, Takeshi Kimoto, Sohei Kawabata, Rika Bian, Yufan Tsubomoto, Makoto Okamura, Kazuya Enwright, John F. Kikuchi, Mitsuru Lewis, David A. Hashimoto, Takanori affil: Department of Psychiatry and Behavioral Science, Kanazawa University Graduate School of Medical Sciences, Kanazawa, 920-8640, Japan sug: subj: Prefrontal Cortex Physiology Bipolar Disorder Physiopathology Schizophrenia Physiopathology Affective Disorders Physiopathology Cognition Disorders GABA Metabolism Neurons Physiology Proteins Metabolism Somatostatin Metabolism Gene Expression Human Polymerase Chain Reaction Body Mass Index RNA, Messenger Analysis Effect Size Funding Source Autopsy Female Male Middle Age Gene Expression Profiling Descriptive Statistics Confidence Intervals Middle Aged: 45-64 years Female Male ab: Background: In schizophrenia (SZ), impairments in cognitive functions, such as working memory, have been associated with alterations in certain types of inhibitory neurons that utilize the neurotransmitter γ -aminobutyric acid (GABA) in the dorsolateral prefrontal cortex (DLPFC). For example, GABA neurons that express parvalbumin (PV) or somatostatin (SST) have more prominent gene expression alterations than those that express vasoactive intestinal peptide (VIP). In bipolar disorder (BD) and major depression (MD), which exhibit similar, but less severe, cognitive impairments than SZ, alterations of transcript levels in GABA neurons have also been reported. However, the extent to which GABA neuron subtype-selective transcripts in the DLPFC are affected, and the relative magnitudes of the diagnosis-associated effects, have not been directly compared across SZ, BD, and MD in the same study. Methods: We used quantitative polymerase chain reaction to examine levels of GABA neuron subtype-selective transcripts (PV, potassium voltage-gated channel modifier subfamily-S member-3, SST, VIP, and calretinin mRNAs), as well as the pan-GABA neuron marker 67 kDa glutamate decarboxylase mRNA, in DLPFC total gray matter of 160 individuals, including those with SZ, BD, or MD and unaffected comparison (UC) individuals. Results: Relative to UC individuals, individuals with SZ exhibited large deficits in levels of all transcripts except for calretinin mRNA, whereas individuals with BD or MD showed a marked deficit only for PV or SST mRNAs, respectively. Conclusions: These findings suggest that broader and more severe alterations in DLPFC GABA neurons might contribute to the greater cognitive impairments in SZ relative to BD and MD. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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