Childhood neglect is associated with alterations in neural prediction error signaling and the response to novelty.
Background: One in eight children experience early life stress (ELS), which increases risk for psychopathology. ELS, particularly neglect, has been associated with reduced responsivity to reward. However, little work has investigated the computational specifics of this disrupted reward response – pa...
| Publicado en: | Psychological Medicine Vol. 54; no. 14; pp. 3930 - 3939 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | diagnostic images equations & formulas pictorial research tables/charts Journal Article |
| Publicado: |
Cambridge University Press
Oct2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=181784351&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 181784351 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00332917 6Q3 jtl: Psychological Medicine issn: 00332917 maglogo: N pubinfo: dt: Oct2024 vid: 54 iid: 14 pid: 15979 pub: Cambridge University Press artinfo: ui: 181784351 181784351 181784351 10.1017/S0033291724002411 181784351 ppf: 3930 ppct: 9 formats: tig: atl: Childhood neglect is associated with alterations in neural prediction error signaling and the response to novelty. aug: au: Aloi, Joseph Crum, Kathleen I. Blair, Karina S. Zhang, Ru Bashford-Largo, Johannah Bajaj, Sahil Hwang, Soonjo Averbeck, Bruno B. Tottenham, Nim Dobbertin, Matthew Blair, R. James R. affil: Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA sug: subj: Child Abuse Complications Adverse Childhood Experiences Complications Brain Pathology Task Performance and Analysis Learning Methods Reward Human Funding Source Child Adolescence Magnetic Resonance Imaging Child Abuse Evaluation Questionnaires Oxygenation Frontal Lobe Paradigms Mental Disorders Risk Factors Risk Assessment Adult Child: 6-12 years Adolescent: 13-18 years Adult: 19-44 years ab: Background: One in eight children experience early life stress (ELS), which increases risk for psychopathology. ELS, particularly neglect, has been associated with reduced responsivity to reward. However, little work has investigated the computational specifics of this disrupted reward response – particularly with respect to the neural response to Reward Prediction Errors (RPE) – a critical signal for successful instrumental learning – and the extent to which they are augmented to novel stimuli. The goal of the current study was to investigate the associations of abuse and neglect, and neural representation of RPE to novel and non-novel stimuli. Methods: One hundred and seventy-eight participants (aged 10–18, M = 14.9, s.d. = 2.38) engaged in the Novelty task while undergoing functional magnetic resonance imaging. In this task, participants learn to choose novel or non-novel stimuli to win monetary rewards varying from $0 to $0.30 per trial. Levels of abuse and neglect were measured using the Childhood Trauma Questionnaire. Results: Adolescents exposed to high levels of neglect showed reduced RPE-modulated blood oxygenation level dependent response within medial and lateral frontal cortices particularly when exploring novel stimuli (p < 0.05, corrected for multiple comparisons) relative to adolescents exposed to lower levels of neglect. Conclusions: These data expand on previous work by indicating that neglect, but not abuse, is associated with impairments in neural RPE representation within medial and lateral frontal cortices. However, there was no association between neglect and behavioral impairments on the Novelty task, suggesting that these neural differences do not necessarily translate into behavioral differences within the context of the Novelty task. pubtype: Academic Journal doctype: diagnostic images equations & formulas pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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