Metabolic Score for Insulin Resistance (METS-IR) Associations with Subclinical Left Ventricular and Left Atrial Remodelling in Young Subjects with Hypertension.
Background: Insulin resistance (IR) is associated with left ventricular (LV) remodeling and eventually leads to cardiovascular events. Recently elaborated metabolic score for IR (METS-IR) is one of noninsulin-based scores for insulin sensitivity estimation. In previous studies, METS-IR was predictiv...
| Publicado en: | Annals of Clinical Cardiology Vol. 6; no. 2; pp. 82 - 88 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wolters Kluwer India Pvt Ltd
Jul-Dec2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=181811662&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 181811662 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 26666979 MUZV jtl: Annals of Clinical Cardiology issn: 26666979 maglogo: N pubinfo: dt: Jul-Dec2024 vid: 6 iid: 2 pid: 16919 pub: Wolters Kluwer India Pvt Ltd artinfo: ui: 181811662 181811662 181811662 10.4103/ACCJ.ACCJ_10_24 181811662 ppf: 82 ppct: 6 formats: tig: atl: Metabolic Score for Insulin Resistance (METS-IR) Associations with Subclinical Left Ventricular and Left Atrial Remodelling in Young Subjects with Hypertension. aug: au: Ezhova, Nadezhda E. Shavarova, Elena K. Kobalava, Zhanna D. Bazdyreva, Elena I. Shavarov, Andrey A. affil: Department of Diagnostic, RUDN University Clinical Hospital, Moscow, Russian Federation sug: subj: Hypertension Insulin Resistance Complications Ventricular Remodeling Heart Atrium, Left Pathology Cardiometabolic Risk Factors Risk Assessment Human Male Female Adolescence Adult Middle Age Cross Sectional Studies Adolescent: 13-18 years Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Background: Insulin resistance (IR) is associated with left ventricular (LV) remodeling and eventually leads to cardiovascular events. Recently elaborated metabolic score for IR (METS-IR) is one of noninsulin-based scores for insulin sensitivity estimation. In previous studies, METS-IR was predictive for incident type 2 diabetes, hypertension, and arterial stiffness. Associations of METS-IR with subclinical myocardial damage were discussed in a few works. Objective: The objective of the study was to investigate relationship between IR estimated with METS-IR and early heart remodeling in young patients with hypertension. Methods: We included 96 hypertensive subjects free of diabetes mellitus aged 18–45 years in prospective cross-sectional study. In each patient, we estimated IR with homeostasis model assessment-estimated IR (HOMA-IR) and METS-IR scores, performed ambulatory blood pressure monitoring and echocardiography including 2D speckle-tracking. Results: Patients with the highest METS-IR quartile had significantly higher left ventricular mass index (LVMI) and differed from patients with lower METS-IR score in some of the diastolic function characteristics but not in LV global longitudinal strain. METS-IR had stronger correlation with most of the echocardiographic features of abnormal LV geometry and function, including LVMI, relative wall thickness, e', E/e', tricuspid regurgitation velocity, left atrial (LA) volume index, and LV global longitudinal strain, than HOMA-IR. In multiple regression analysis METS-IR was independently associated with LVMI (B = 0.80 [0.37; 1.22], P < 0.0001) and LA reservoir stain (LARs) (B = −0.40 (−0.57; −0.23), P < 0.0001). Conclusion: Noninsulin-based index of IR METS-IR is independently associated with LV and LA remodeling in young subjects with hypertension. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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