IPNA clinical practice recommendations for the diagnosis and management of children with IgA nephropathy and IgA vasculitis nephritis.

IgA nephropathy and IgA vasculitis with nephritis, albeit rare, represent two relatively frequent glomerular conditions in childhood. Compared to adults, pediatric IgA nephropathy has a more acute presentation, most frequently with synpharyngitic macrohematuria and histologically with more intense i...

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Publicado en:Pediatric Nephrology Vol. 40; no. 2; pp. 533 - 570
Autores principales: Vivarelli, Marina, Samuel, Susan, Coppo, Rosanna, Barratt, Jonathan, Bonilla-Felix, Melvin, Haffner, Dieter, Gibson, Keisha, Haas, Mark, Abdel-Hafez, Maher Ahmed, Adragna, Marta, Brogan, Paul, Kim, Siah, Liu, Isaac, Liu, Zhi-Hong, Mantan, Mukta, Shima, Yuko, Shimuzu, Masaki, Shen, Qian, Trimarchi, Hernan, Hahn, Deirdre
Formato: algorithm glossary tables/charts Journal Article
Publicado: Springer Nature Feb2025
Acceso en línea:Ver este registro en EBSCOhost
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        atl: IPNA clinical practice recommendations for the diagnosis and management of children with IgA nephropathy and IgA vasculitis nephritis.
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          Vivarelli, Marina
          Samuel, Susan
          Coppo, Rosanna
          Barratt, Jonathan
          Bonilla-Felix, Melvin
          Haffner, Dieter
          Gibson, Keisha
          Haas, Mark
          Abdel-Hafez, Maher Ahmed
          Adragna, Marta
          Brogan, Paul
          Kim, Siah
          Liu, Isaac
          Liu, Zhi-Hong
          Mantan, Mukta
          Shima, Yuko
          Shimuzu, Masaki
          Shen, Qian
          Trimarchi, Hernan
          Hahn, Deirdre
        affil: https://ror.org/02sy42d13 Laboratory of Nephrology, Bambino Gesù Children's Hospital, IRCCS, Piazza S. Onofrio 4 00165, Rome, Italy
      sug:
        subj:
          Immunoglobulins
          Glomerulonephritis Diagnosis
          Purpura, Schoenlein-Henoch Diagnosis
          Practice Guidelines
          Glomerulonephritis Therapy
          Purpura, Schoenlein-Henoch Therapy
          Severity of Illness
          Patient Assessment
          Clinical Indicators
          Biopsy
          Hematuria
          Proteinuria
          Disease Progression Risk Factors
          Risk Assessment
          After Care
          Diet
          Body Weight
          Exercise
          Glucocorticoids Therapeutic Use
          Immunosuppressive Agents Therapeutic Use
          Nephrotic Syndrome Drug Therapy
          Cyclophosphamide Therapeutic Use
          Azathioprine Therapeutic Use
          Rituximab Therapeutic Use
          Hydroxychloroquine
          Vitamin D Administration and Dosage
          Immunization
          Dietary Supplementation
          Fish Oils
          Child
          Recurrence Diagnosis
          Recurrence Drug Therapy
          Child: 6-12 years
      ab: IgA nephropathy and IgA vasculitis with nephritis, albeit rare, represent two relatively frequent glomerular conditions in childhood. Compared to adults, pediatric IgA nephropathy has a more acute presentation, most frequently with synpharyngitic macrohematuria and histologically with more intense inflammation and less intense chronic damage. Management of these conditions is controversial and supported by little high-quality evidence. The paucity of evidence is due to the disease heterogeneity, its inter-ethnic variability, and the difficulty of extrapolating data from adult studies due to the peculiarities of the condition in children. IgA vasculitis with nephritis is a kidney manifestation of a systemic disorder, typical of the pediatric age, in which both the diagnosis of kidney involvement and its management are poorly defined, and an interdisciplinary approach is crucial. Both conditions can have a profound and long-lasting impact on kidney function and the global health of affected children. The International Pediatric Nephrology Association has therefore convened a diverse international group of experts from different disciplines to provide guidance on the recommended management of these conditions in children and to establish common definitions and define priorities for future high-quality, evidence-based collaborative studies for the benefit of children.
      pubtype: Academic Journal
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        algorithm
        glossary
        tables/charts
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    language: English
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