Is overweight a predictor for a more severe course of disease in cases of necrotizing fasciitis?
Purpose: Necrotizing fasciitis is a rare but severe soft tissue infection, and its diagnosis is difficult and often delayed. Immediate treatment comprising extensive debridement, highly dosed broad-spectrum antibiotic therapy and intensive care is necessary to prevent fatal outcomes. Considering the...
| Publicado en: | European Journal of Trauma & Emergency Surgery Vol. 50; no. 6; pp. 3319 - 3329 |
|---|---|
| Autores principales: | , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Dec2024
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=181829374&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 181829374 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 18639933 3C05 jtl: European Journal of Trauma & Emergency Surgery issn: 18639933 maglogo: N pubinfo: dt: Dec2024 vid: 50 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 181829374 179270721 181829374 181829374 10.1007/s00068-024-02638-0 181829374 ppf: 3319 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Is overweight a predictor for a more severe course of disease in cases of necrotizing fasciitis? aug: au: Illg, Claudius Denzinger, Markus Rachunek, Katarzyna Farzaliyev, Farhad Thiel, Johannes T. Daigeler, Adrien Krauss, Sabrina affil: https://ror.org/03a1kwz48 Department of Hand, Plastic, Reconstructive and Burn Surgery, BG Unfallklinik Tuebingen, Eberhard Karls University Tuebingen, Schnarrenbergstrasse 95, 72076, Tuebingen, Germany sug: subj: Fasciitis, Necrotizing Pathology Severity of Illness Disease Progression Risk Factors Obesity Risk Assessment Fasciitis, Necrotizing Therapy Treatment Outcomes Fasciitis, Necrotizing Mortality Human Retrospective Design Record Review Trauma Centers Germany Sepsis Comparative Studies Body Weight Respiration, Artificial Catecholamines Therapeutic Use Treatment Duration Fatal Outcome ab: Purpose: Necrotizing fasciitis is a rare but severe soft tissue infection, and its diagnosis is difficult and often delayed. Immediate treatment comprising extensive debridement, highly dosed broad-spectrum antibiotic therapy and intensive care is necessary to prevent fatal outcomes. Considering the global rise in overweight patients and the known negative effects of obesity on the immune system, the aim of this study was to analyze whether overweight results in a more severe course of necrotizing fasciitis, worse outcomes and an increased mortality rate among overweight patients compared than in normal weight patients. Methods: The present study involved a retrospective analysis of 29 patients who were treated for necrotizing fasciitis in our level one trauma center during the eight-year period between 2013 and 2020. Based on their BMIs, the patients were assigned to either the overweight group (BMI > 25) or the normal weight group. Results: In the study population, being overweight appeared to be a predictor for a more severe course of necrotizing fasciitis. Overweight patients suffered from sepsis significantly more often than normal weight patients (13 vs. 5; p = 0.027). Furthermore, they were dependent on invasive ventilation (26.6 ± 33.8 vs. 5.9 ± 11.9 days; p = 0.046) as well as catecholamine support (18.4 ± 23.7 vs. 3.6 ± 5.7 days; p = 0.039) for significantly longer. Conclusion: Necrotizing fasciitis remains a challenging and potentially fatal disease. Within the patient collective, the severity of the disease and treatment effort were increased among overweight patients. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|