Developing a Screening Strategy to Identify Hepatotoxicity and Drug Interaction Potential of Botanicals.
Botanical supplements, herbal remedies, and plant-derived products are used globally. However, botanical dietary supplements are rarely subjected to robust safety testing unless there are adverse reports in post-market surveillance. Botanicals are complex and difficult to assess using current framew...
| Publicado en: | Journal of Dietary Supplements Vol. 22; no. 1; pp. 162 - 193 |
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| Autores principales: | , , , , , , , , , , , , , |
| Formato: | pictorial review tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=181834699&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 181834699 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19390211 2Y62 jtl: Journal of Dietary Supplements issn: 19390211 maglogo: N pubinfo: dt: 2025 vid: 22 iid: 1 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 181834699 180452108 181834699 181834699 10.1080/19390211.2024.2417679 181834699 ppf: 162 ppct: 31 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Developing a Screening Strategy to Identify Hepatotoxicity and Drug Interaction Potential of Botanicals. aug: au: Roe, Amy L. Krzykwa, Julie Calderón, Angela I. Bascoul, Cécile Gurley, Bill J. Koturbash, Igor Li, Albert P. Liu, Yitong Mitchell, Constance A. Oketch-Rabah, Hellen Si, Lin van Breemen, Richard B. Walker, Heather Ferguson, Stephen S. affil: Procter & Gamble Healthcare, Cincinnati, OH, USA sug: subj: Health Screening Hepatotoxicity Diagnosis Plants, Medicinal Adverse Effects Plant Extracts Adverse Effects Phytochemicals Adverse Effects Dietary Supplements Adverse Effects Drug-Herb Interactions Medicine, Herbal Patient Safety Xenobiotics Metabolism ab: Botanical supplements, herbal remedies, and plant-derived products are used globally. However, botanical dietary supplements are rarely subjected to robust safety testing unless there are adverse reports in post-market surveillance. Botanicals are complex and difficult to assess using current frameworks designed for single constituent substances (e.g. small molecules or discrete chemicals), making safety assessments costly and time-consuming. The liver is a primary organ of concern for potential botanical-induced hepatotoxicity and botanical-drug interactions as it plays a crucial role in xenobiotic metabolism. The NIH-funded Drug Induced Liver Injury Network noted that the number of botanical-induced liver injuries in 2017 nearly tripled from those observed in 2004–2005. New approach methodologies (NAMs) can aid in the rapid and cost-effective assessment of botanical supplements for potential hepatotoxicity. The Hepatotoxicity Working Group within the Botanical Safety Consortium is working to develop a screening strategy that can help reliably identify potential hepatotoxic botanicals and inform mechanisms of toxicity. This manuscript outlines the Hepatotoxicity Working Group's strategy and describes the assays selected and the rationale for the selection of botanicals used in case studies. The selected NAMs evaluated as a part of this effort are intended to be incorporated into a larger battery of assays to evaluate multiple endpoints related to botanical safety. This work will contribute to a botanical safety toolkit, providing researchers with tools to better understand hepatotoxicity associated with botanicals, prioritize and plan future testing as needed, and gain a deeper insight into the botanicals being tested. pubtype: Academic Journal doctype: pictorial review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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