Association between total, regional and organ fat and type 2 diabetes risk factors among Latino youth: A longitudinal study.
Summary: Introduction: To examine whether within‐person changes in total, regional and organ fat were associated with within‐person changes in type 2 diabetes (T2D)‐related biomarkers following interventions. Methods: A secondary analysis from a randomised trial among Latino youth (30 males, 25 fema...
| Publicado en: | Pediatric Obesity Vol. 20; no. 1; pp. 1 - 7 |
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| Autores principales: | , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Jan2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=181889417&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 181889417 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20476302 ETV7 jtl: Pediatric Obesity issn: 20476302 maglogo: Y pubinfo: dt: Jan2025 vid: 20 iid: 1 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 181889417 180916322 181889417 181889417 10.1111/ijpo.13185 181889417 ppf: 1 ppct: 6 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Association between total, regional and organ fat and type 2 diabetes risk factors among Latino youth: A longitudinal study. aug: au: Owolabi, Eyitayo O. Olson, Micah L. Hu, Houchun H. Peña, Armando Pimentel, Janiel L. Pituch, Keenan A. Bailey, Smita S. Shaibi, Gabriel Q. affil: Center for Health Promotion and Disease Prevention, Edson College of Nursing and Health Innovation, Arizona State University, Phoenix Arizona,, USA sug: subj: Body Organs Adipose Tissue Distribution Diabetes Mellitus, Type 2 Risk Factors Risk Assessment Hispanic Americans In Infancy and Childhood Hispanic Americans In Adolescence Biological Markers Pediatric Obesity Therapy Life Style Changes Human Correlational Studies Prospective Studies Secondary Analysis Male Female Child Adolescence Absorptiometry, Photon Magnetic Resonance Imaging Adipose Tissue Insulin Sensitivity Fat Free Mass Blood Glucose Funding Source Child: 6-12 years Adolescent: 13-18 years Male Female ab: Summary: Introduction: To examine whether within‐person changes in total, regional and organ fat were associated with within‐person changes in type 2 diabetes (T2D)‐related biomarkers following interventions. Methods: A secondary analysis from a randomised trial among Latino youth (30 males, 25 females) aged 12–16 years with obesity. The study sample combined participants randomised to either lifestyle intervention (N = 39) or usual care (N = 16). Total body composition was assessed by DEXA. Hepatic and pancreatic fat fractions were assessed using MRI. T2D risk factors included insulin sensitivity, beta‐cell function and post‐challenge glucose. Results: Significant changes in %body fat, lean mass, insulin sensitivity and 2‐h glucose were observed. Changes in fat mass were associated with changes in insulin sensitivity (β = −0.45, p < 0.001), while changes in lean mass were associated with changes in 2‐h glucose concentrations (β = −0.50, p = 0.02). No association between changes in total, regional, or organ fat and beta cell function were noted. Conclusions: Our study revealed that within‐person changes in fat mass and lean mass were associated with increased insulin sensitivity and reduced 2‐h glucose concentrations, respectively, among high‐risk Latino youth. The impact of reductions in regional and organ fat deposition on T2D risk factors warrants further examination. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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