Association of immune-mediated diseases with the risk of dementia and brain structure in UK Biobank participants.
Background Immunity and inflammation may be essential to the pathogenesis of dementia. However, the association of immune-mediated diseases with the risk of incident dementia has not been well characterised. Objectives We aimed to investigate the prospective association of 27 immune-mediated disease...
| Published in: | Age & Ageing Vol. 53; no. 12; pp. 1 - 11 |
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| Main Authors: | , , , , , , , , , , , , |
| Format: | Article |
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Oxford University Press / USA
Dec2024
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| Subjects: | |
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=181894289&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 181894289 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00020729 AGA jtl: Age & Ageing issn: 00020729 maglogo: N pubinfo: dt: Dec2024 vid: 53 iid: 12 pid: 622 pub: Oxford University Press / USA artinfo: ui: 181894289 10.1093/ageing/afae274 ppf: 1 ppct: 10 formats: tig: atl: Association of immune-mediated diseases with the risk of dementia and brain structure in UK Biobank participants. aug: au: Cai, Jinhua Rong, Heng Chen, Jiongxue Deng, Zhenhong Chen, Sitai Liao, Huanquan Pan, Dong Chen, Yanting Shi, Zhongshan Li, Yi Li, Honghong Xu, Yongteng Tang, Yamei affil: Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China Department of Neurology, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, People's Republic of China Department of Neurology, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, People's Republic of China Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China Guangdong Province Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People's Republic of China su: United Kingdom Uk Biobank Ltd. Immunologic diseases Dementia risk factors Risk assessment Research funding Brain Descriptive statistics Longitudinal method Odds ratio Tissue banks White matter (Nerve tissue) Dementia Confidence intervals Inflammation Regression analysis Nosology Dementia patients Comorbidity Proportional hazards models Disease incidence Disease complications sug: subj: Immunologic diseases United Kingdom Uk Biobank Ltd. Blood and Organ Banks Dementia risk factors Risk assessment Research funding Brain Descriptive statistics Longitudinal method Odds ratio Tissue banks White matter (Nerve tissue) Dementia Confidence intervals Inflammation Regression analysis Nosology Dementia patients Comorbidity Proportional hazards models Disease incidence Disease complications keyword: Alzheimer's disease brain structure dementia immune-mediated disease older people UK Biobank Alzheimer's disease brain structure dementia immune-mediated disease older people UK Biobank ab: Background Immunity and inflammation may be essential to the pathogenesis of dementia. However, the association of immune-mediated diseases with the risk of incident dementia has not been well characterised. Objectives We aimed to investigate the prospective association of 27 immune-mediated diseases and incident dementia risk and to explore the underlying mechanisms driven by brain structures. Methods We included 487 459 UK Biobank participants aged 37–73 years without dementia at enrolment. Immune-mediated diseases and dementia cases were ascertained according to the International Classification of Diseases codes. Time-varying Cox proportional hazards regression and general linear regression models were used to examine the association of immune-mediated disease with incident dementia risk and brain morphometric measures, respectively. Results Over a median follow-up of 12.3 years, 1654 cases of incident dementia were documented in 86 243 patients with immune-mediated diseases. Overall, immune-mediated diseases were associated with a higher all-cause dementia risk (hazard ratio [HR], 1.24; 95% confidence interval, 1.17–1.32). Five out of 27 immune-mediated diseases were associated with an increased risk of dementia individually. Comorbidity of multiple immune-mediated diseases further increased the risk. Moreover, the immune-mediated disease was associated with smaller total surface areas of both left (β, −286.51; SE, 102.58; P =.014) and right hemispheres (β, −298.56; SE, 103.96; P =.016), greater white matter hyperintensities volume (β, 1.02; SE, 0.13; P <.001) and less healthy white matter microstructures. Conclusions Immune-mediated diseases were associated with an increased risk of incident dementia, and the association of those diseases with brain structural abnormalities might provide clues to the underlying mechanisms. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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