Occult Breast Cancer in High-Risk Gene-Positive Pakistani Women Undergoing Contralateral Prophylactic Mastectomy/Prophylactic Mastectomy: Implications for Sentinel Lymph Node Biopsy.
Introduction: Sentinel lymph node biopsy (SLNB) of the axilla is standard in breast cancer (BC) management; however, its role in prophylactic/contralateral prophylactic mastectomy (CPM) is still questioned. To avoid future consequences on surgical morbidity and socioeconomic aspects in low and middl...
| Publicado en: | Breast Cancer: Basic & Clinical Research pp. 1 - 7 |
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| Autores principales: | , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Sage Publications Inc.
1/2/2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=182025258&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 182025258 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 11782234 B078 jtl: Breast Cancer: Basic & Clinical Research issn: 11782234 maglogo: Y pubinfo: dt: 1/2/2025 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 182025258 182025258 182025258 10.1177/11782234241311018 182025258 ppf: 1 ppct: 6 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Occult Breast Cancer in High-Risk Gene-Positive Pakistani Women Undergoing Contralateral Prophylactic Mastectomy/Prophylactic Mastectomy: Implications for Sentinel Lymph Node Biopsy. aug: au: Mooghal, Mehwish Khan, Wajiha Anjum, Saba Shaikh, Hafsa Virji, Safna Naozer Vohra, Lubna M affil: Section of Breast Surgery, Department of Surgery, The Aga Khan University Hospital, Karachi, Pakistan sug: subj: Breast Neoplasms Epidemiology Breast Neoplasms Surgery Breast Neoplasms Risk Factors Prophylactic Mastectomy Sentinel Lymph Node Biopsy Women Psychosocial Factors Neoplasms, Unknown Primary Risk Assessment Human Female Adult Middle Age Pakistan Retrospective Design Record Review Prospective Studies Descriptive Statistics Data Analysis Software Academic Medical Centers Pakistan Prevalence Surgical Patients Adult: 19-44 years Middle Aged: 45-64 years Female ab: Introduction: Sentinel lymph node biopsy (SLNB) of the axilla is standard in breast cancer (BC) management; however, its role in prophylactic/contralateral prophylactic mastectomy (CPM) is still questioned. To avoid future consequences on surgical morbidity and socioeconomic aspects in low and middle-income countries (LMICs), we intend to determine the prevalence of occult breast cancer (OBC) among CPM cases. Objective: To determine the prevalence of OBC in patients undergoing prophylactic mastectomy (PM). Design: This is a retrospective cohort study. Materials and methods: This retrospective cohort study is conducted at a tertiary-care hospital from January 2017 to December 2022. All individuals with the positive genetic test for high-risk breast cancer (HRBC) genes who underwent PMs/CPM at our centre were included. We analysed data using SPSS version 23.0. Results: Twenty-six mutation-positive females underwent PM/CPM (16.1%). Two (7.69%) of 26 had later post-PM recurrence. Only 8 (30.76%) patients had SLNB and all were negative. No OBC was seen in PM/CPM specimens, whereas 3 (11.5%) had atypical ductal hyperplasia (ADH). Two of the ADH had BI-RADS-1, whereas 1 was BI-RADS-4 (33.3%) on the preoperative assessment. Results also showed that with an increase in the tumour grade of the diseased breast, the BI-RADS score of the asymptomatic breast was subsequently increased (P =.029). Conclusion: Our study shows negative OBCs in PM/CPM cases with persistently negative SLNB results; however, ADH is identified in 11.5% of specimens. Our results suggest that SLNB can be safely omitted in patients undergoing CPM, but, preoperatively, patient and disease factors should be considered. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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