Curcumin as a complementary treatment in oncological therapy: a systematic review.
Purpose: Curcumin, the active ingredient in turmeric, is employed by numerous cancer patients to support conventional cancer therapy. This systematic review aims to summarize the existing clinical evidence and to provide an overview of the potential benefits and risks associated with curcumin supple...
| Publicado en: | European Journal of Clinical Pharmacology Vol. 81; no. 1; pp. 1 - 34 |
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| Autores principales: | , , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
Springer Nature
Jan2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=182077093&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 182077093 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00316970 NP9 jtl: European Journal of Clinical Pharmacology issn: 00316970 maglogo: N pubinfo: dt: Jan2025 vid: 81 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 182077093 180325309 182077093 182077093 10.1007/s00228-024-03764-9 182077093 ppf: 1 ppct: 33 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Curcumin as a complementary treatment in oncological therapy: a systematic review. aug: au: Gutsche, Lisa C. Dörfler, Jennifer Hübner, Jutta affil: https://ror.org/03kxagd85 Klinik für Innere Medizin II, Hämatologie und Internistische Onkologie, Universitätsklinikum Jena, 07747, Am Klinikum 1, Jena, Germany sug: subj: Neoplasms Drug Therapy Curcumin Therapeutic Use Curcumin Adverse Effects Dietary Supplements Alternative Therapies Drug Efficacy Human Male Female Adult Middle Age Aged Aged, 80 and Over Systematic Review Embase Cochrane Library Psycinfo CINAHL Database Medline Curcumin Administration and Dosage Body Weight Changes Body Composition Survival Rate Disease Progression Stomatitis Vomiting Chemically Induced Head and Neck Neoplasms Drug Therapy Breast Neoplasms Drug Therapy Prostatic Neoplasms Drug Therapy Colorectal Neoplasms Drug Therapy Cancer Patients Checklists Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Male Female ab: Purpose: Curcumin, the active ingredient in turmeric, is employed by numerous cancer patients to support conventional cancer therapy. This systematic review aims to summarize the existing clinical evidence and to provide an overview of the potential benefits and risks associated with curcumin supplementation. Methods: In January 2024, we conducted a systematic search of five electronic databases (Embase, Cochrane, PsycInfo, CINAHL, and Medline) using a complex search strategy. We included randomized controlled trials on the use, effectiveness, and potential harm of additional curcumin therapy in adult patients under cancer treatment. The risk of bias was assessed using Cochrane revised Risk of Bias Tool 2.0. Results: This systematic review included 34 randomized controlled trials involving 2580 patients out of 11143 search results. Included patients were primarily diagnosed with head and neck cancer, followed by breast, prostate, and colorectal cancer. Therapy concepts encompassed topical or systemic curcumin administration. The studies reported heterogeneous results concerning oral and skin symptoms, pain, weight alteration and changes in body composition, survival, and disease progression. Significant findings were reported for oral mucositis and weight loss. Considering risk of bias, all studies had moderate to high risk of bias. Regarding side effects, one study reported significantly more vomiting in the curcumin group. Conclusion: Although the results suggest promise in reducing mucositis and weight loss, a clear statement regarding the effectiveness of curcumin therapy on cancer patients cannot be made due to heterogeneous results and methodological limitations of the involved studies. Further investigations of higher quality are necessary to derive a definite recommendation for action. pubtype: Academic Journal doctype: research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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