Cover Image
QR Code

Effects of Renal Denervation on the Course of Cardiorenal Syndrome: Insight From Studies With Fawn-Hooded Hypertensive Rats.

Combination of chronic kidney disease (CKD) and heart failure (HF) results in extremely high morbidity and mortality. The current guideline-directed medical therapy is rarely effective and new therapeutic approaches are urgently needed. The study was designed to examine if renal denervation (RDN) wi...

Full description

Published in:Physiological Research Vol. 73; pp. 737 - 755
Main Authors: DOUL, Jan, GAWRYS, Olga, ŠKAROUPKOVÁ, Petra, VAŇOURKOVÁ, Zdenka, SZEIFFOVÁ BAČOVÁ, Barbara, SÝKORA, Matúš, MAXOVÁ, Hana, HOŠKOVÁ, Lenka, ŠNOREK, Michal, SADOWSKI, Janusz, TÁBORSKÝ, Miloš, ČERVENKA, Luděk
Format: Journal Article
Published: Institute of Physiology, Academy of Sciences of the Czech Republic 2024 Supplement
Online Access:View this record in EBSCOhost
fields @attributes:
  recordID: 1
pdfLink:
plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=182115415&site=ehost-live
header:
  @attributes:
    shortDbName: ccm
    uiTerm: 182115415
    longDbName: CINAHL Complete
    uiTag: AN
  controlInfo:
    bkinfo:
    dissinfo:
    jinfo:
      jid:
        08628408
        1CVW
      jtl: Physiological Research
      issn: 08628408
      maglogo: N
    pubinfo:
      dt: 2024 Supplement
      vid: 73
      pid: 24634
      pub: Institute of Physiology, Academy of Sciences of the Czech Republic
    artinfo:
      ui:
        182115415
        10.33549/physiolres.935469
        182115415
      ppf: 737
      ppct: 18
      formats:
        fmt:
          @attributes:
            type: P
      tig:
        atl: Effects of Renal Denervation on the Course of Cardiorenal Syndrome: Insight From Studies With Fawn-Hooded Hypertensive Rats.
      aug:
        au:
          DOUL, Jan
          GAWRYS, Olga
          ŠKAROUPKOVÁ, Petra
          VAŇOURKOVÁ, Zdenka
          SZEIFFOVÁ BAČOVÁ, Barbara
          SÝKORA, Matúš
          MAXOVÁ, Hana
          HOŠKOVÁ, Lenka
          ŠNOREK, Michal
          SADOWSKI, Janusz
          TÁBORSKÝ, Miloš
          ČERVENKA, Luděk
        affil: Department of Pathophysiology, The Second Faculty of Medicine, Charles University, Prague, Czech Republic
      sug:
      ab: Combination of chronic kidney disease (CKD) and heart failure (HF) results in extremely high morbidity and mortality. The current guideline-directed medical therapy is rarely effective and new therapeutic approaches are urgently needed. The study was designed to examine if renal denervation (RDN) will exhibit longstanding beneficial effects on the HF- and CKD-related morbidity and mortality. Fawn-hooded hypertensive rats (FHH) served as a genetic model of CKD and fawn-hooded low-pressure rats (FHL) without CKD served as controls. HF was induced by creation of aorto-caval fistula (ACF). RDN was performed 28 days after creation of ACF and the follow-up period was 70 days. ACF FHH subjected to sham-RDN had survival rate of 34 % i.e. significantly lower than 79 % observed in sham-denervated ACF FHL. RDN did not improve the condition and the final survival rate, both in ACF FHL and in ACF FHH. In FHH basal albuminuria was markedly higher than in FHL, and further increased throughout the study. RDN did not lower albuminuria and did not reduce renal glomerular damage in FHH. In these rats creation of ACF resulted in marked bilateral cardiac hypertrophy and alterations of cardiac connexin-43, however, RDN did not modify any of the cardiac parameters. Our present results further support the notion that kidney damage aggravates the HF-related morbidity and mortality. Moreover, it is clear that in the ACF FHH model of combined CKD and HF, RDN does not exhibit any important renoprotective or cardioprotective effects and does not reduce mortality.
      pubtype: Academic Journal
      doctype: Journal Article
      ougenre: Article
    language: English
    refInfo:
    holdings:
      @attributes:
        islocal: N