Correlation of inflammatory markers and NFATC4 gene expression among subjects with prediabetes.
Introduction: Prediabetes, characterized by mildly elevated blood sugar levels, significantly increases the risk of developing type 2 diabetes and cardiovascular disease. The condition is linked to higher levels of IL-18, TNF-α, and IL-6, indicating inflammation that may drive type 2 Diabetes Mellit...
| Publicado en: | Journal of Cardiovascular & Thoracic Research Vol. 16; no. 4; pp. 264 - 275 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Tabriz University of Medical Sciences
Dec2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=182169616&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 182169616 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20085117 BL7R jtl: Journal of Cardiovascular & Thoracic Research issn: 20085117 maglogo: N pubinfo: dt: Dec2024 vid: 16 iid: 4 pid: 69573 pub: Tabriz University of Medical Sciences artinfo: ui: 182169616 182169616 182169616 10.34172/jcvtr.33272 182169616 ppf: 264 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Correlation of inflammatory markers and NFATC4 gene expression among subjects with prediabetes. aug: au: Rajan, Aswathi L, Karpagavel S, Vidya K S, Sheena M D, Harilal S, Deepthi K, Manjusha Raveendran, Rachana P V, Ambili T M, Midhun T, Swathi D, Dinesh Roy affil: Chettinad Academy of Research and Education (Deemed to be University), Kelambakkam, Chennai, Tamil Nadu, India sug: subj: Inflammation Biological Markers Transcription Factors Gene Expression Prediabetic State Anthropometry Life Style Human Case Control Studies Young Adult Adult Middle Age Interleukins ROC Curve Multiple Regression Thyrotropin Triglycerides Adult: 19-44 years Middle Aged: 45-64 years ab: Introduction: Prediabetes, characterized by mildly elevated blood sugar levels, significantly increases the risk of developing type 2 diabetes and cardiovascular disease. The condition is linked to higher levels of IL-18, TNF-α, and IL-6, indicating inflammation that may drive type 2 Diabetes Mellitus (T2DM). Despite the known role of inflammation in glucose homeostasis, the involvement of the Nuclear Factor of Activated T Cells 4 (NFATC4) gene in prediabetes remains underexplored. This case-control study aims to investigate the association between physiological, demographic, anthropometric, lifestyle factors, inflammatory markers and NFATC4 gene expression, in the context of prediabetes. Methods: The study involved 300 participants aged 20 to 50, with 150 diagnosed with prediabetes and 150 healthy controls. After obtaining informed consent fasting venous blood samples were collected for comprehensive assessments, including biochemical, endocrinological and immunological analyses. Specifically, NFATC4 gene expression and inflammatory markers were measured. Results: The findings revealed significantly elevated levels of IL-18, TNF-α, IL-6, and NFATC4 expression in prediabetic individuals compared to controls. Notably, strong positive correlations were observed between NFATC4 expression and the inflammatory markers. Receiver operating characteristic (ROC) curve analysis identified IL-18 and NFATC4 as the most promising biomarkers for predicting prediabetes, followed by TNF-α and IL-6. Multivariate regression analysis further identified socioeconomic status (SES), IL-18, NFATC4, TSH, triglycerides, and HDL as independent predictors of prediabetes. Conclusion: These results highlight the key role of inflammation and NFATC4 in prediabetes, stressing the need for strategies to prevent progression to type 2 diabetes and cardiovascular issues. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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