Mitochondrial Influence on Performance Fatigability: Considering Sex Variability.
Objective: Existing literature indicates that females generally demonstrate higher fatigue resistance than males during isometric contractions. However, when it comes to single-limb dynamic exercises, the intricate interplay between performance fatigability (PF), cardiovascular responses, and muscle...
| Publicado en: | Medicine & Science in Sports & Exercise Vol. 57; no. 2; pp. 376 - 390 |
|---|---|
| Autores principales: | , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
Feb2025
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=182188613&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 182188613 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01959131 4DP jtl: Medicine & Science in Sports & Exercise issn: 01959131 maglogo: N pubinfo: dt: Feb2025 vid: 57 iid: 2 pid: 433 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 182188613 182188613 182188613 10.1249/MSS.0000000000003558 182188613 ppf: 376 ppct: 14 formats: tig: atl: Mitochondrial Influence on Performance Fatigability: Considering Sex Variability. aug: au: GIURIATO, GAIA BARBI, CHIARA LAGINESTRA, FABIO GIUSEPPE ANDANI, MEHRAN EMADI FAVARETTO, THOMAS MARTIGNON, CAMILLA PEDRINOLLA, ANNA VERNILLO, GIANLUCA MORO, TATIANA FRANCHI, MARTINO ROMANELLI, MARIA GRAZIA SCHENA, FEDERICO VENTURELLI, MASSIMO affil: Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, ITALY sug: subj: Mitochondria Metabolism Muscle Fatigue Evaluation Exercise Task Performance and Analysis Human Male Female Adult In Vitro Studies Muscles Metabolism Sex Factors Therapeutic Exercise Methods Neurologic Examination Heart Rate Blood Pressure Isometric Exercises Quadriceps Muscles Physiology Funding Source Adult: 19-44 years Male Female ab: Objective: Existing literature indicates that females generally demonstrate higher fatigue resistance than males during isometric contractions. However, when it comes to single-limb dynamic exercises, the intricate interplay between performance fatigability (PF), cardiovascular responses, and muscle metabolism in relation to sex differences remains underexplored. Purpose: This study investigates how sex affects the relationship between muscle oxidative characteristics and the development of PF during dynamic single-leg exercise. Methods: Twenty-four young healthy participants (12 males vs 12 females) performed a constant-load single-leg knee extension task (85% peak power output; 60 rpm) to exhaustion (TTE). Neuromuscular assessments via transcranial magnetic and peripheral stimulations were conducted before and after exercise to evaluate central and peripheral factors of PF. Vastus lateralis muscle biopsies were obtained for mitochondrial respiration and immunohistochemistry analyses. Results: Participants performed similar total work (28 ± 7 vs 27 ± 14 kJ, P = 0.81) and TTE (371 ± 139 vs 377 ± 158 s, P = 0.98); after the TTE, females' maximal isometric voluntary contraction (MVIC: −36% ± 13% vs −24% ± 9%, P = 0.006) and resting twitch (RT; −65% ± 9% vs −40% ± 24%, P = 0.004) force declined less. No differences were observed in supraspinal neuromuscular factors (P > 0.05). During exercise, the cardiovascular responses differed between sexes. Although fiber type composition was similar (type I: 47% ± 13% vs 56% ± 14%, P = 0.11), males had lower mitochondrial net oxidative capacity (61 ± 30 vs 89 ± 37, P = 0.049) and higher Complex II contribution to maximal respiration (CII; 59% ± 8% vs 48% ± 6%, P < 0.001), which correlated with the decline in MVIC (r = −0.74, P < 0.001) and RT (r = −0.60, P = 0.002). Conclusions: Females display greater resistance to PF during dynamic contractions, likely due to their superior mitochondrial efficiency and lower dependence on mitochondrial CII activity. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|