Serum Levels of Factor XIII, D-dimer, and Fibrinogen as A non- Invasive Diagnostic Biomarkers in Patients with Venous Thromboembolism.
Background & Objective: Using new diagnostic methods to help quickly diagnose VTE disease is important. It is well known that treatment of VTE is based on radiological methods, but the main purpose of this research was to investigate the relationship between blood coagulation factor XIII( FXIII), D-...
| Publicado en: | Journal of Advances in Medical & Biomedical Research Vol. 32; no. 154; pp. 341 - 350 |
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| Autores principales: | , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Zanjan University of Medical Sciences & Health Services
Sep/Oct2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=182224072&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 182224072 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 26766264 N5MJ jtl: Journal of Advances in Medical & Biomedical Research issn: 26766264 maglogo: N pubinfo: dt: Sep/Oct2024 vid: 32 iid: 154 pid: 65276 pub: Zanjan University of Medical Sciences & Health Services artinfo: ui: 182224072 182224072 182224072 10.30699/jambs.32.154.341 182224072 ppf: 341 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Serum Levels of Factor XIII, D-dimer, and Fibrinogen as A non- Invasive Diagnostic Biomarkers in Patients with Venous Thromboembolism. aug: au: Bandpey, Hossein Omranpour Qujeq, Durdi Ranaee, Mohammad Monadi, Mahmoud affil: Department of Internal Medicine, Ayatollah Rouhani Hospital, School of Medicine, Babol University of Medical Sciences, Babol, Iran. sug: subj: Blood Coagulation Factors Blood Fibrin Fibrinogen Degradation Products Blood Fibrinogen Blood Biological Markers Blood Venous Thromboembolism Radiography Venous Thromboembolism Therapy Human Funding Source Male Female Adult Middle Age Aged Aged, 80 and Over Prospective Studies Case Control Studies Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Male Female ab: Background & Objective: Using new diagnostic methods to help quickly diagnose VTE disease is important. It is well known that treatment of VTE is based on radiological methods, but the main purpose of this research was to investigate the relationship between blood coagulation factor XIII( FXIII), D-dimer, and fibrinogen levels in patients with VTE. Materials & Methods: Seventy patients initially suspected of having VTE were included and determined their D-dimer, fibrinogen, and (FXIII )levels. The diagnosis of VTE was based on the CT-Angiography. The blood samples were prepared from the patients during the first 6 hours of admission and before using anticoagulant. Results: The mean level of D-dimer in VTE patients was higher than those without VTE (1770± 764.49 vs. 430.66± 263.98ng / ml) (p <0.001). The mean factor XIII level in patients with VTE was significantly lower than those without VTE(55.03±13.61 vs. 88.57±18.14ng / ml) (p <0.001). The mean fibrinogen level in patients with VTE was significantly lower than in non-VTE patients (140.49± 36.03 vs. 214.69± 69.73 mg/dl) (p <0.001). The cut-off value of D-dimer was 500 ng/ml, and the sensitivity and specificity were 97% and 74%, respectively. The cutoff point of fibrinogen was 168 mg/dl, with a sensitivity of and a specificity of 77% and 77%, respectively. The cut-off point of XIII was 70 ng/ml, with a sensitivity of and specificity85% and 82%, respectively. Conclusion: Our findings suggest that combined measurement of serum levels of D-dimer, factor XIII, and fibrinogen can be used to confirm clinical suspicion for VTE. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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