Modeling the Dynamics of Addiction Relapse via the Double-Well Potential System.

Substance use relapse is difficult to define, and previous work has used one-size-fits-all ad hoc definitions. Researchers have called for a dynamic and personalized understanding of relapse as a concept and model, necessitating novel statistical tools. We aimed to develop and validate a novel stati...

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Publicado en:Journal of Psychopathology & Clinical Science Vol. 134; no. 1; pp. 69 - 81
Autores principales: Fatimah, Haya, Hunter, Michael D., Bornovalova, Marina A.
Formato: Artículo
Publicado: American Psychological Association Jan2025
Materias:
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Jan2025
      vid: 134
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      pub: American Psychological Association
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        182245467
        10.1037/abn0000960
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        atl: Modeling the Dynamics of Addiction Relapse via the Double-Well Potential System.
      aug:
        au:
          Fatimah, Haya
          Hunter, Michael D.
          Bornovalova, Marina A.
        affil:
          Department of Psychology, University of Notre Dame
          Department of Human Development and Family Studies, Pennsylvania State University
          Department of Psychology, University of South Florida
      su:
        Substance abuse relapse
        Substance abuse
        Criminal behavior
        Life satisfaction
        Dynamical systems
      sug:
        subj:
          Substance abuse relapse
          Substance abuse
          Criminal behavior
          Life satisfaction
          Dynamical systems
      keyword:
        addiction
        dynamical systems model of relapse
        relapse
        substance use
        addiction
        dynamical systems model of relapse
        relapse
        substance use
      ab: Substance use relapse is difficult to define, and previous work has used one-size-fits-all ad hoc definitions. Researchers have called for a dynamic and personalized understanding of relapse as a concept and model, necessitating novel statistical tools. We aimed to develop and validate a novel statistical model of latent relapse processes: the double-well potential model (DWPM). This model describes posttreatment substance use in terms of a dynamical system with stable equilibria of abstinence and relapse, person-specific dominant equilibria (tilt), the ease of changing between equilibria (steepness), and an overall relapse risk (RR). Using timeline follow-back data from N = 139 adults with a substance use disorder transitioning back to the community after residential treatment, we examined individual differences and the criterion-related validity of DWPM parameters to determine the clinical utility of the double-well model. While nonuse was the predominant stable state across participants, we found significant between-subjects variability steepness and RR. These individual differences were predictable via demographics, baseline psychopathology, treatment history, and treatment condition. Steepness and RR also predicted long-term outcomes, including life satisfaction and criminal behavior, above and beyond traditional metrics of relapse (proportion of days used and time to first use). Thus, the DWPM is a strong theoretical and statistical representation of the underlying relapse processes. Moreover, the parameters show criterion-related validity and may be useful in precision medicine. General Scientific Summary: Researchers have called for a dynamic and personalized understanding of relapse as a concept and model. We offer a nonlinear dynamical system—a double-well potential model that defines relapse in terms of two equilibria (an abstinence well and use well) of a continuous dynamical system—with individual random effects as one such dynamic and personalized understanding of relapse. We apply this model in a sample of substance users returning to the community and reporting on their daily substance use. We find that model parameters show construct validity and have promise for clinical utility.
      pubtype: Academic Journal
      doctype: Article
      src: R
    language: English
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