The effect of combined fig-Walnut syrup on functional constipation in pregnant women: a randomized controlled trial.

Background: Constipation is one of the most common gastrointestinal complaints during pregnancy. Consuming fruits and vegetables is often the first line of treatment due to their fiber content. Therefore, the purpose of the present study was to determine the effect of combined fig-walnut syrup on fu...

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Publicado en:Nutrition & Metabolism Vol. 22; no. 1; pp. 1 - 17
Autores principales: Valizadeh, Roghayyeh, Mohammad-Alizadeh-Charandabi, Sakineh, Hajizadeh, Khadijeh, Araj-Khodaei, Mostafa, Mirghafourvand, Mojgan
Formato: research tables/charts randomized controlled trial Journal Article
Publicado: BioMed Central 1/17/2025
Acceso en línea:Ver este registro en EBSCOhost
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      dt: 1/17/2025
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        10.1186/s12986-025-00895-3
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        atl: The effect of combined fig-Walnut syrup on functional constipation in pregnant women: a randomized controlled trial.
      aug:
        au:
          Valizadeh, Roghayyeh
          Mohammad-Alizadeh-Charandabi, Sakineh
          Hajizadeh, Khadijeh
          Araj-Khodaei, Mostafa
          Mirghafourvand, Mojgan
        affil: https://ror.org/04krpx645 Department of Midwifery, Faculty of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran
      sug:
        subj:
          Constipation In Pregnancy
          Nuts
          Women Psychosocial Factors
          Dietary Supplements
          Quality of Life
          Human
          Female
          Adult
          Randomized Controlled Trials
          Random Assignment
          Pregnancy
          Double-Blind Studies
          Questionnaires
          One-Way Analysis of Variance
          Analysis of Covariance
          Mann-Whitney U Test
          Kruskal-Wallis Test
          Descriptive Statistics
          Confidence Intervals
          Funding Source
          Adult: 19-44 years
          Female
      ab: Background: Constipation is one of the most common gastrointestinal complaints during pregnancy. Consuming fruits and vegetables is often the first line of treatment due to their fiber content. Therefore, the purpose of the present study was to determine the effect of combined fig-walnut syrup on functional constipation (FC) and quality of life (QoL) in pregnant women. Methods: In this double-blind, randomized controlled clinical trial, 90 pregnant women with FC were randomly assigned to receive combined fig-walnut syrup, fig syrup, or placebo (n = 30 in each group) using block randomization. Participants received 15 ml of syrup once daily at night, half an hour before bedtime, for 14 days and were followed up for 2 weeks after the end of the intervention. The FC, quality of life-gravidity (QOL-GRAV), and food frequency questionnaires (FFQ) were used to collect data. The questionnaires were completed once before the intervention and then the FC questionnaire was completed once a week for four weeks and the QoL questionnaire was completed at the end of the fourth week. To compare the outcomes among the study groups, one-way AONOVA, ANCOVA, Mann- Whitney U test, and Kruskal- Wallis test were used. Results: Following the intervention, although there was no statistically significant difference in the number of defecations between the combined fig-walnut syrup group and the fig syrup group (P > 0.05) at every four weeks, there was a statistically significant difference compared to the placebo (P < 0.05). Combined fig-walnut syrup (adjusted mean difference (AMD): -3.4; 95% confidence interval: -0.7 to -6.1; P = 0.008) and fig syrup (AMD: -5.8; 95% CI: -3.1 to -8.6; P < 0.001) improved QoL compared to the placebo group and there was no statistically significant difference between the combined fig-walnut and fig syrup (AMD: 2.4; 95% CI: 5.2 to -0.3; P = 0.104). Conclusion: The consumption of fig-walnut syrup and fig syrup may help improve constipation symptoms and enhance QoL during pregnancy. Further studies are needed to reach a conclusive determination. Trial registration: Iranian Registry of Clinical Trials (IRCT): IRCT2012071801032N79. Date of registration: 07.12.2023.
      pubtype: Academic Journal
      doctype:
        research
        tables/charts
        randomized controlled trial
        Journal Article
      ougenre: Article
    language: English
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