Synthesis, preclinical assessment, and first-in-human study of [18F]d4-FET for brain tumor imaging.

Purpose: Tumor-to-background ratio (TBR) is a critical metric in oncologic PET imaging. This study aims to enhance the TBR of [18F]FET in brain tumor imaging by substituting deuterium ("D") for hydrogen ("H"), thereby improving the diagnostic sensitivity and accuracy. Methods: [18F]d4-FET was synthe...

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Publicado en:	European Journal of Nuclear Medicine & Molecular Imaging Vol. 52; no. 3; pp. 864 - 876
Autores principales:	Hou, Lu, Chen, Zhiyong, Chen, Fanfan, Sheng, Lianghe, Ye, Weijian, Dai, Yingchu, Guo, Xiaoyu, Dong, Chenchen, Li, Guocong, Liao, Kai, Li, Yinlong, Ma, Jie, Wei, Huiyi, Ran, Wenqing, Shang, Jingjie, Ling, Xueying, Patel, Jimmy S., Liang, Steven H., Xu, Hao, Wang, Lu
Formato:	Journal Article
Publicado:	Springer Nature Feb2025
Acceso en línea:	Ver este registro en EBSCOhost