Acute effects of beetroot extract and resveratrol ingestion on cardiovascular and cardiac autonomic modulation recovery after moderate-intensity aerobic exercise in individuals with coronary artery disease: a triple-blinded, randomized, placebo-controlled trial

Purpose: This study aimed to evaluate the acute effects of beetroot extract and resveratrol supplementation (isolated and combined) on cardiac autonomic modulation and cardiovascular parameters recovery after exercise in individuals with coronary artery disease (CAD). Methods: 14 males with CAD were...

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Published in:European Journal of Nutrition Vol. 64; no. 2; pp. 1 - 12
Main Authors: Gonzaga, Luana Almeida, Porto, Andrey Alves, Takahashi, Carolina, Gomes, Rayana Loch, Vanderlei, Luiz Carlos Marques, Valenti, Vitor Engrácia
Format: pictorial research tables/charts randomized controlled trial Journal Article
Published: Springer Nature Mar2025
Online Access:View this record in EBSCOhost
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      dt: Mar2025
      vid: 64
      iid: 2
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      pub: Springer Nature
      place: New York, New York
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        10.1007/s00394-025-03582-4
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        atl: Acute effects of beetroot extract and resveratrol ingestion on cardiovascular and cardiac autonomic modulation recovery after moderate-intensity aerobic exercise in individuals with coronary artery disease: a triple-blinded, randomized, placebo-controlled trial
      aug:
        au:
          Gonzaga, Luana Almeida
          Porto, Andrey Alves
          Takahashi, Carolina
          Gomes, Rayana Loch
          Vanderlei, Luiz Carlos Marques
          Valenti, Vitor Engrácia
        affil: https://ror.org/00987cb86 Postgraduate Program in Movement Sciences, Universidade Estadual Paulista (UNESP), Presidente Prudente, São Paulo, Brazil
      sug:
        subj:
          Beet Therapeutic Use
          Plant Extracts Therapeutic Use
          Resveratrol Therapeutic Use
          Dietary Supplementation
          Cardiovascular System Physiology
          Autonomic Nervous System Physiology
          Recovery, Exercise
          Aerobic Exercises
          Combined Modality Therapy
          Treatment Outcomes
          Coronary Arteriosclerosis
          Human
          Funding Source
          Male
          Female
          Adult
          Middle Age
          Aged
          Aged, 80 and Over
          Randomized Controlled Trials
          Random Assignment
          Triple-Blind Studies
          Descriptive Statistics
          Heart Rate Variability
          Cardiorespiratory Fitness
          Time
          Relaxation
          Blood Pressure
          Adult: 19-44 years
          Middle Aged: 45-64 years
          Aged: 65+ years
          Aged, 80 & over
          Male
          Female
      ab: Purpose: This study aimed to evaluate the acute effects of beetroot extract and resveratrol supplementation (isolated and combined) on cardiac autonomic modulation and cardiovascular parameters recovery after exercise in individuals with coronary artery disease (CAD). Methods: 14 males with CAD were submitted to 4 protocols consisting of 30 min (min) of rest, 30 min of aerobic exercise on a treadmill (60% of the heart rate reserve HRR), followed by 30 min of recovery. Before each protocol, the subjects consumed 500 mg of starch (placebo protocol), 500 mg of beetroot (beetroot protocol), or 500 mg of resveratrol (resveratrol protocol), or 500 mg of beetroot and 500 mg of resveratrol (combined protocol). Heart rate variability (HRV) indices and cardiorespiratory parameters were determined at different times during the protocols. Results: Regarding HR, significantly higher values about rest in the placebo protocol at all recovery moments (1st to 30th min) were observed. Significant differences were observed in the other protocols (beetroot, resveratrol and combined) from the first to the 20th min recovery. For SBP, significantly higher values concerning rest were observed at the first minute of recovery for all protocols. No differences were found for the HRV index between time and protocols. Conclusions: The single supplementation of beetroot and resveratrol (isolated and combined) did not alter HRV and cardiovascular parameter responses between protocols. The consumption of beetroot extract and resveratrol enhanced vagal modulation and heart rate recovery compared to rest.
      pubtype: Academic Journal
      doctype:
        pictorial
        research
        tables/charts
        randomized controlled trial
        Journal Article
      ougenre: Article
    language: English
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