Effects of lorazepam on saccadic eye movements – evidence from prosaccade and free viewing tasks.
Rationale: Peak velocities of saccadic eye movements are reduced after benzodiazepine administration. Even though this is an established effect, past research has only examined it in horizontal prosaccade tasks. Objectives: The spectrum of saccadic eye movements, however, is much larger. Therefore,...
| Publicado en: | Psychopharmacology Vol. 242; no. 2; pp. 271 - 285 |
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| Autores principales: | , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Feb2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=182538121&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 182538121 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00333158 EJD jtl: Psychopharmacology issn: 00333158 maglogo: N pubinfo: dt: Feb2025 vid: 242 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 182538121 179410154 10.1007/s00213-024-06672-z 182538121 ppf: 271 ppct: 14 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Effects of lorazepam on saccadic eye movements – evidence from prosaccade and free viewing tasks. aug: au: Baumert, Philine M. Faßbender, Kaja Wintergerst, Maximilian W. M. Terheyden, Jan H. Aslan, Behrem Foulsham, Tom Harmening, Wolf Ettinger, Ulrich affil: https://ror.org/041nas322 Department of Psychology, University of Bonn, Kaiser-Karl-Ring 9, 53111, Bonn, Germany sug: ab: Rationale: Peak velocities of saccadic eye movements are reduced after benzodiazepine administration. Even though this is an established effect, past research has only examined it in horizontal prosaccade tasks. Objectives: The spectrum of saccadic eye movements, however, is much larger. Therefore, we aimed to make a first attempt at filling this research gap by testing benzodiazepine effects on saccades under different experimental task conditions. Methods: 1 mg lorazepam or placebo was administered (within-subjects, double-blind, in randomised order) to n = 30 healthy adults. Participants performed an extended version of the prosaccade task, including vertical saccade directions and different stimulus eccentricities, as well as a free viewing task. Results: Results from the prosaccade task confirmed established effects of benzodiazepines as well as saccade direction on saccadic parameters but additionally showed that the drug effect on peak velocity was independent of saccade direction. Remarkably, in the free viewing task peak velocities as well as other saccade parameters were unaffected by lorazepam. Furthermore, exploration patterns during free viewing did not change under lorazepam. Conclusions: Overall, our findings further consolidate the peak velocity of prosaccades as a biomarker of sedation. Additionally, we suggest that sedative effects of low doses of benzodiazepines may be compensated in tasks that more closely resemble natural eye movement behaviour, possibly due to the lack of time constraints or via neurophysiological processes related to volition. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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