Glucagon-like peptide-1 receptor agonists and capsule endoscopy in patients with diabetes: a matched cohort study.
Video capsule endoscopy (VCE) is valuable for assessing conditions like GI bleeding, anemia, and inflammatory bowel disease. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are prescribed for diabetes and weight loss, with their pharmacologic effects including delayed gastric emptying. This stu...
| Publicado en: | Gastrointestinal Endoscopy Vol. 101; no. 2; pp. 393 - 402 |
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| Autores principales: | , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Elsevier B.V.
Feb2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=182567879&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 182567879 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00165107 4A9 jtl: Gastrointestinal Endoscopy issn: 00165107 maglogo: N pubinfo: dt: Feb2025 vid: 101 iid: 2 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 182567879 182567879 182567879 10.1016/j.gie.2024.07.014 182567879 ppf: 393 ppct: 9 formats: tig: atl: Glucagon-like peptide-1 receptor agonists and capsule endoscopy in patients with diabetes: a matched cohort study. aug: au: Odah, Tarek Vattikonda, Asrita Stark, Mark Brahmbhatt, Bhaumik Lukens, Frank J. Badurdeen, Dilhana Hashash, Jana G. Farraye, Francis A. affil: Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, Florida, USA sug: subj: Glucagon-Like Peptide-1 Receptor Agonists Therapeutic Use Capsule Endoscopy Diabetes Mellitus Drug Therapy Human Prospective Studies Retrospective Design Record Review Diabetic Patients Matched Case Control Time Factors Descriptive Statistics Multivariate Analysis Confidence Intervals Intestine, Small Gastrointestinal Transit Gastrointestinal Motility Drug Effects ab: Video capsule endoscopy (VCE) is valuable for assessing conditions like GI bleeding, anemia, and inflammatory bowel disease. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are prescribed for diabetes and weight loss, with their pharmacologic effects including delayed gastric emptying. This study investigates the impact of GLP-1RA use on VCE outcomes in patients with diabetes. This retrospective cohort study involves patients with diabetes undergoing VCE while on GLP-1RAs matched in a 1:1 ratio with control subjects, who are not on GLP-1RAs, based on demographics and diabetes-related factors. The primary outcome was gastric transit time in VCE studies, whereas secondary outcomes were incomplete small-bowel evaluation and small-bowel transit time. In the GLP-1RA cohort with 68 patients, 5 (7%) experienced failure to pass the video capsule through the stomach; all control subjects passed the video capsule successfully (P =.06). GLP-1RA patients had a longer gastric transit time (99.3 ± 134.2 minutes) compared with control subjects (25.3 ± 31.6 minutes, P <.001). Multivariate analysis revealed GLP-1RA use was associated with an increased gastric transit time by 74.5 minutes (95% confidence interval, 33.8-115.2; P <.001) compared with control subjects, after adjusting for relevant factors. Sixteen GLP-1RA patients (23.5%) experienced incomplete passage of the video capsule through the small intestine, a significantly higher rate compared with 3 patients in the control group (4.4%, P <.01). GLP-1RA use is associated with a prolonged gastric transit time and a higher rate of incomplete small-bowel evaluation during VCE. Future studies may be crucial for evaluating strategies to mitigate these effects. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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