A combination of Citrus aurantifolia fruit rind and Theobroma cacao seed extracts supplementation enhances metabolic rates in overweight subjects: a randomized, placebo-controlled, cross-over study.
Background and objective: LN19183 is a proprietary, synergistic combination of Citrus aurantifolia fruit rind and Theobroma cacao seed extracts that increased resting energy expenditure (REE) in high-fat diet (HFD)- fed obese rats. The objective of this study was to validate the thermogenic potentia...
| Published in: | Food & Nutrition Research Vol. 68; pp. 1 - 15 |
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| Main Authors: | , , , , , |
| Format: | pictorial research tables/charts randomized controlled trial Journal Article |
| Published: |
Swedish Nutrition Foundation
2024
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=182622958&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 182622958 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16546628 55M4 jtl: Food & Nutrition Research issn: 16546628 maglogo: N pubinfo: dt: 2024 vid: 68 pid: 46341 pub: Swedish Nutrition Foundation artinfo: ui: 182622958 182622958 182622958 10.29219/fnr.v68.10745 182622958 ppf: 1 ppct: 14 formats: tig: atl: A combination of Citrus aurantifolia fruit rind and Theobroma cacao seed extracts supplementation enhances metabolic rates in overweight subjects: a randomized, placebo-controlled, cross-over study. aug: au: Ammatalli, Nihal Kumar Reddy Kuricheti, Sesha Sai Siva Krishna Veeramachaneni, Sudipta Yean Kyoung Koo Ramanathan, Guru Yalamanchi, Amulya affil: Department of General Medicine, Anu Hospital, Suryaraopet, Vijayawada, India sug: subj: Plant Extracts Citrus Therapeutic Use Cacao Therapeutic Use Dietary Supplementation Basal Metabolic Rate Drug Effects Obesity Prevention and Control Treatment Outcomes Body Weight Adipose Tissue Animal Studies Rats In Vivo Studies Human Randomized Controlled Trials Random Assignment Male Female Double-Blind Studies Crossover Design Funding Source Male Female ab: Background and objective: LN19183 is a proprietary, synergistic combination of Citrus aurantifolia fruit rind and Theobroma cacao seed extracts that increased resting energy expenditure (REE) in high-fat diet (HFD)- fed obese rats. The objective of this study was to validate the thermogenic potential of LN19183 in obese Sprague Dawley (SD) rats and to assess its clinical efficacy in a proof-of-concept, randomized, placebo-controlled, cross-over human trial. Methods: In the rat study, HFD-fed obese rats were supplemented with either HFD alone or with 45, 90, or 180 mg LN19183 per kg body weight (BW) for 28 days. In the human study, 60 overweight adults (male and female, aged 20--39 years) were randomized. Subjects took LN19183 (450 mg) or a matched placebo capsule on two consecutive days in phases one and two of the study, separated by a 10-day washout period. In each phase, on day 1, REE at pre-dose, 60-, 120-, and 180-min post-dose, and on day 2, metabolic rates at pre-dose and post-dose during and 20 min after exercise were measured using indirect calorimetry. Results: In rats, LN19183 significantly increased REE, reduced BW gain and fat masses, and increased fat and carbohydrate metabolism marker proteins including beta 3 adrenergic receptor (β3-AR), phospho-AMP-activated protein kinase (AMPK), glucagon-like peptide-1 receptor (GLP-1R) in the liver, and serum adiponectin levels. Furthermore, LN19183-supplemented human volunteers increased (P < 0.05, vs. placebo) the metabolic rates at rest and with exercise; their fat oxidation was increased (P < 0.05, vs. placebo) at rest and 20 min post-exercise. The groups' systolic and diastolic blood pressure (BP), heart rates (HR), and safety parameters were comparable. Conclusion: These observations suggest that LN19183 is a thermogenic botanical composition with no stimulatory effects on BP and HR. pubtype: Academic Journal doctype: pictorial research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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