Lactate-enhanced-qSOFA (LqSOFA) score as a predictor of in-hospital mortality in patients with sepsis: systematic review and meta-analysis.
Introduction: Sepsis is a systemic process that refers to a deregulated immune response of the host against an infectious agent, involving multiple organ dysfunction. It is rapidly progressive and has a dismal prognosis, with high mortality rates. For this reason, it is necessary to have a tool for...
| Publicado en: | European Journal of Trauma & Emergency Surgery Vol. 51; no. 1; pp. 1 - 14 |
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| Autores principales: | , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=182632995&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 182632995 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 18639933 3C05 jtl: European Journal of Trauma & Emergency Surgery issn: 18639933 maglogo: N pubinfo: dt: 2025 vid: 51 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 182632995 10.1007/s00068-024-02757-8 182632995 ppf: 1 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Lactate-enhanced-qSOFA (LqSOFA) score as a predictor of in-hospital mortality in patients with sepsis: systematic review and meta-analysis. aug: au: Moncada-Gutiérrez, Diego Vásquez-Tirado, Gustavo Adolfo Meregildo-Rodríguez, Edinson Dante Quispe-Castañeda, Claudia Vanessa Cuadra-Campos, María Abanto-Montalván, Percy Hernán Guzmán-Aguilar, Wilson Marcial Liñán-Díaz, Leslie Jacqueline Alva-Guarniz, Hugo Nelson Rodríguez-Chávez, Luis Ángel affil: https://ror.org/03eek8g24 Facultad de Medicina Humana, Universidad Privada Antenor Orrego, Trujillo, Perú sug: ab: Introduction: Sepsis is a systemic process that refers to a deregulated immune response of the host against an infectious agent, involving multiple organ dysfunction. It is rapidly progressive and has a dismal prognosis, with high mortality rates. For this reason, it is necessary to have a tool for early recognition of these patients, with the aim of treating them appropriately in a timely manner. Methods: This research is a systematic review based on bibliography indexed in four online scientific databases for studies published since inception to February 2024, which was obtained through the use of a search strategy. Eight studies were identified for quantitative analysis and included in our meta-analysis. Results: The meta-analysis revealed that among 23,551 patients diagnosed with sepsis, 5,825 had a positive LqSOFA, and 3,086 experienced the primary outcome (mortality). For LqSOFA, a sensitivity of 0.61 (95% CI 0.60–0.63), specificity of 0.81 (95% CI 0.80–0.81), positive likelihood ratio (LR+) of 3.46 (95% CI 2.86–4.18), negative likelihood ratio (LR-) of 0.47 (95% CI 0.38–0.59), and odds ratio (OR) of 7.43 (95% CI 6.01–9.20) were determined. The area under the curve (AUC) was 0.807. Conclusions: The LqSOFA score demonstrates a good predictive capacity for in-hospital mortality in septic patients, showing clinically significant levels of sensitivity (69%) and specificity (79%). pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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