Individual and mixture analyses of the associations of phenols and phthalates with lung function among US adults.
The effects of endocrine disruptors including phenols and phthalates on adult lung function remain unclear. In the present study, data from 2007–2012 National Health and Nutrition Examination Survey (NHANES) were extracted, and 4338 participants were included in the final analyses. The associations...
| Publicado en: | International Journal of Environmental Health Research Vol. 35; no. 2; pp. 330 - 345 |
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| Autores principales: | , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Feb2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=182633767&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 182633767 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09603123 57L jtl: International Journal of Environmental Health Research issn: 09603123 maglogo: Y pubinfo: dt: Feb2025 vid: 35 iid: 2 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 182633767 177122827 182633767 182633767 10.1080/09603123.2024.2352609 182633767 ppf: 330 ppct: 15 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Individual and mixture analyses of the associations of phenols and phthalates with lung function among US adults. aug: au: Wang, Chenchen Wang, Huaicheng Cai, Jinpeng Xu, Xi affil: Center for Molecular Metabolism, Nanjing University of Science and Technology, Nanjing, P. R. China sug: subj: Lung Physiology Respiratory Tract Physiology Evaluation Phenols Plasticizers Environmental Exposure Human Questionnaires Respiratory Function Tests United States Linear Regression Forced Expiratory Volume Vital Capacity Peak Expiratory Flow Rate Adult Funding Source Adult: 19-44 years ab: The effects of endocrine disruptors including phenols and phthalates on adult lung function remain unclear. In the present study, data from 2007–2012 National Health and Nutrition Examination Survey (NHANES) were extracted, and 4338 participants were included in the final analyses. The associations of three phenols and four phthalate metabolites with six lung function parameters were investigated. In generalized linear regression models (GLM) and restricted cubic spline (RCS) analyses, bisphenol A (BPA) was associated with decreased forced expiratory volume in the first second (FEV1) and forced vital capacity (FVC), and 2,5-dichlorophenol (DCP) was associated with reduced FEV1, FVC and peak expiratory flow rate (PEF), and increased prevalence of restrictive lung function (RLF) in adults. Furthermore, weighted quantile sum (WQS) regression and Bayesian kernel machine regression (BKMR) models demonstrated that mixed exposures to phenols and phthalates were linked to reduced FEV1, FVC and PEF and increased prevalence of RLF, and these associations were mainly driven by BPA and 2,5-DCP. In conclusion, mixed exposure to phenols and phthalates was linked to compromised and a restrictive pattern of lung function. The mechanisms of the effects of phenol and phthalate exposures on lung function and respiratory diseases need to be further investigated. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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