Profiling Autism and Attention Deficit Hyperactivity Disorder Traits in Children with SYNGAP1-Related Intellectual Disability.
SYNGAP1-related ID is a genetic condition characterised by global developmental delay and epilepsy. Individuals with SYNGAP1-related ID also commonly show differences in attention and social communication/interaction and frequently receive additional diagnoses of Autism Spectrum Disorder (ASD) or At...
| Publicado en: | Journal of Autism & Developmental Disorders Vol. 55; no. 1; pp. 297 - 310 |
|---|---|
| Autores principales: | , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jan2025
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=182844497&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 182844497 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01623257 AUT jtl: Journal of Autism & Developmental Disorders issn: 01623257 maglogo: N pubinfo: dt: Jan2025 vid: 55 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 182844497 174038681 182844497 182844497 10.1007/s10803-023-06162-9 182844497 ppf: 297 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Profiling Autism and Attention Deficit Hyperactivity Disorder Traits in Children with SYNGAP1-Related Intellectual Disability. aug: au: Wright, Damien Kenny, Aisling Mizen, Lindsay A. M. McKechanie, Andrew G. Stanfield, Andrew C. affil: https://ror.org/01nrxwf90 Patrick Wild Centre, Division of Psychiatry, Kennedy Tower, Royal Edinburgh Hospital, University of Edinburgh, EH10 5HF, Edinburgh, UK sug: subj: Genes Mutation Intellectual Disability Diagnosis Autism Spectrum Disorder Familial and Genetic Attention Deficit Hyperactivity Disorder Familial and Genetic Attention Deficit Hyperactivity Disorder Symptoms Social Behavior Human Funding Source Male Female Child, Preschool Child Autism Spectrum Disorder Diagnosis Attention Deficit Hyperactivity Disorder Diagnosis Nervous System Pathology Child, Preschool: 2-5 years Child: 6-12 years Male Female ab: SYNGAP1-related ID is a genetic condition characterised by global developmental delay and epilepsy. Individuals with SYNGAP1-related ID also commonly show differences in attention and social communication/interaction and frequently receive additional diagnoses of Autism Spectrum Disorder (ASD) or Attention Deficit Hyperactivity Disorder (ADHD). We thus set out to quantify ASD and ADHD symptoms in children with this syndrome. To assess ASD and ADHD, parents and caregivers of a child with SYNGAP1-related ID (N = 34) or a typically developing control (N = 21) completed the Social Responsiveness Scale-2, the Social Communication Questionnaire with a subset of these also completing the Conners-3. We found that those with SYNGAP1-related ID demonstrated higher levels of autistic traits on both the SRS and SCQ than typically developing controls. On the SRS, those with SYNGAP1-related ID scored highest for restricted repetitive behaviours, and were least impaired in social awareness. On the Conners-3, those with SYNGAP1-related ID also showed a high prevalence of ADHD traits, with scores demonstrating difficulties with peer relations but relatively low occurrence of symptoms for DSM-5 conduct disorder and DSM-5 oppositional defiant disorder. Hierarchical clustering analysis highlighted distinct SYNGAP1-related ID subgroups for both ASD and ADHD traits. These findings provide further characterisation of the SYNGAP1-related ID behavioural phenotype, guiding diagnosis, assessment and potential interventions. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|