Motor Signature Differences Between Autism Spectrum Disorder and Developmental Coordination Disorder, and Their Neural Mechanisms.
Autism spectrum disorder (ASD) and Developmental Coordination Disorder (DCD) are distinct clinical groups with overlapping motor features. We attempted to (1) differentiate children with ASD from those with DCD, and from those typically developing (TD) (ages 8–17; 18 ASD, 16 DCD, 20 TD) using a 5-mi...
| Publicado en: | Journal of Autism & Developmental Disorders Vol. 55; no. 1; pp. 353 - 369 |
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| Autores principales: | , , , , , , , , |
| Formato: | diagnostic images pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jan2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=182844498&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 182844498 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01623257 AUT jtl: Journal of Autism & Developmental Disorders issn: 01623257 maglogo: N pubinfo: dt: Jan2025 vid: 55 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 182844498 174048914 182844498 182844498 10.1007/s10803-023-06171-8 182844498 ppf: 353 ppct: 16 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Motor Signature Differences Between Autism Spectrum Disorder and Developmental Coordination Disorder, and Their Neural Mechanisms. aug: au: Butera, Christiana Delafield-Butt, Jonathan Lu, Szu-Ching Sobota, Krzysztof McGowan, Timothy Harrison, Laura Kilroy, Emily Jayashankar, Aditya Aziz-Zadeh, Lisa affil: https://ror.org/03taz7m60 USC Mrs. T.H. Chan Division of Occupational Science and Occupational Therapy, University of Southern California, Los Angeles, CA, USA sug: subj: Autism Spectrum Disorder Physiopathology Autism Spectrum Disorder Radiography Motor Skills Disorders Diagnosis Motor Skills Disorders Physiopathology Magnetic Resonance Imaging Methods Machine Learning Motor Skills Evaluation Human Male Female Child Adolescence Videorecording Kinematics Computers, Hand-Held Early Diagnosis Neurosciences Balance, Postural Psychomotor Performance Brain Physiopathology Brain Radiography Data Analysis Software Descriptive Statistics Funding Source Child: 6-12 years Adolescent: 13-18 years Male Female ab: Autism spectrum disorder (ASD) and Developmental Coordination Disorder (DCD) are distinct clinical groups with overlapping motor features. We attempted to (1) differentiate children with ASD from those with DCD, and from those typically developing (TD) (ages 8–17; 18 ASD, 16 DCD, 20 TD) using a 5-min coloring game on a smart tablet and (2) identify neural correlates of these differences. We utilized standardized behavioral motor assessments (e.g. fine motor, gross motor, and balance skills) and video recordings of a smart tablet task to capture any visible motor, behavioral, posture, or engagement differences. We employed machine learning analytics of motor kinematics during a 5-min coloring game on a smart tablet. Imaging data was captured using functional magnetic resonance imaging (fMRI) during action production tasks. While subject-rated motor assessments could not differentiate the two clinical groups, machine learning computational analysis provided good predictive discrimination: between TD and ASD (76% accuracy), TD and DCD (78% accuracy), and ASD and DCD (71% accuracy). Two kinematic markers which strongly drove categorization were significantly correlated with cerebellar activity. Findings demonstrate unique neuromotor patterns between ASD and DCD relate to cerebellar function and present a promising route for computational techniques in early identification. These are promising preliminary results that warrant replication with larger samples. pubtype: Academic Journal doctype: diagnostic images pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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