Altered temporal lobe connectivity is associated with psychotic symptoms in drug–naïve adolescent patients with first–episode schizophrenia.
Research on individuals with a younger onset age of schizophrenia is important for identifying neurobiological processes derived from the interaction of genes and the environment that lead to the manifestation of schizophrenia. Schizophrenia has long been recognized as a disorder of dysconnectivity,...
| Published in: | European Child & Adolescent Psychiatry Vol. 34; no. 1; pp. 237 - 248 |
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| Main Authors: | , , , , , , , , , |
| Format: | diagnostic images research tables/charts Journal Article |
| Published: |
Springer Nature
Jan2025
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=182882989&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 182882989 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10188827 EJ3 jtl: European Child & Adolescent Psychiatry issn: 10188827 maglogo: N pubinfo: dt: Jan2025 vid: 34 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 182882989 177645390 182882989 182882989 10.1007/s00787-024-02485-9 182882989 ppf: 237 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Altered temporal lobe connectivity is associated with psychotic symptoms in drug–naïve adolescent patients with first–episode schizophrenia. aug: au: Li, Hongwei Zhang, Wenjing Song, Hui Zhuo, Lihua Yao, Hongchao Sun, Hui Liu, Ruishan Feng, Ruohan Tang, Chungen Lui, Su affil: https://ror.org/011ashp19 Department of Radiology, and Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, No. 37 Guoxue Xiang, 610041, Chengdu, China sug: subj: Temporal Lobe Physiopathology Functional Connectivity Evaluation Temporal Lobe Radiography Schizophrenia Physiopathology Psychotic Disorders Symptoms Neural Pathways Human China Male Female Adolescence Funding Source Insular Cortex Magnetic Resonance Imaging Prefrontal Cortex Hallucinations Etiology Hallucinations Physiopathology Adolescent: 13-18 years Male Female ab: Research on individuals with a younger onset age of schizophrenia is important for identifying neurobiological processes derived from the interaction of genes and the environment that lead to the manifestation of schizophrenia. Schizophrenia has long been recognized as a disorder of dysconnectivity, but it is largely unknown how brain connectivity changes are associated with psychotic symptoms. Twenty-one adolescent-onset schizophrenia (AOS) patients and 21 matched healthy controls (HCs) were recruited and underwent resting-state functional magnetic resonance imaging. Regional homogeneity (ReHo) was used to investigate local brain connectivity alterations in AOS. Regions with significant ReHo changes in patients were selected as "seeds" for further functional connectivity (FC) analysis and Granger causality analysis (GCA), and associations of the obtained functional brain measures with psychotic symptoms in patients with AOS were examined. Compared with HCs, AOS patients showed significantly increased ReHo in the right middle temporal gyrus (MTG), which was positively correlated with PANSS-positive scores, PSYRATS-delusion scores and auditory hallucination scores. With the MTG as the seed, lower connectivity with the bilateral postcentral gyrus (PCG) and higher connectivity with the right precuneus were observed in patients. The reduced FC between the right MTG and bilateral PCG was significantly and positively correlated with hallucination scores. GCA indicated decreased Granger causality from the right MTG to the left middle frontal gyrus (MFG) and from the right MFG to the right MTG in AOS patients, but such effects did not significantly associate with psychotic symptoms. Abnormalities in the connectivity within the MTG and its connectivity with other networks were identified and were significantly correlated with hallucination and delusion ratings. This region may be a key neural substrate of psychotic symptoms in AOS. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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