| Sumario: | Objective: This systematic review and bibliometric analysis investigated the keywords appearing most in the pregnancy-related eye disease field to elucidate the current state and trends of pregnancy-related eye disease research. Methods: A systematic literature analysis of pregnancy-related eye disease was performed using the Web of Science Core Collection (WOS) databases. We used the keywords "ocular" OR "eye*" and "pregnancy" OR "pregnant" OR "gestation" to search for articles published from 1999 to 2022. Study data were analyzed and visualized using VOSviewer and CiteSpace. Results: We analyzed 929 articles published from 1999 to 2022. From 1999 to 2012, the article number increased slowly, with a marked acceleration in publication frequency after 2013, original papers accounted for 780 (84%) of the total number of articles published. David A. Mackey was the most prolific writer, and Margaret A. Honein contributed the most citations. The American Journal of Ophthalmology, PLOS One, and the European Journal of Ophthalmology published the most articles. The American Journal of Ophthalmology, Ophthalmology, British Journal of Ophthalmology, Investigative Ophthalmology and Visual Science were the four most commonly cited journals. The University of Western Australia, the University of Sao Paulo, and the University of Melbourne were highly prolific institutions. Five co-cited references had a citation burst up to 2022, analyzed by CiteSpace. Keyword analysis (VOSviewer) yielded recent key themes (pregnancy, women, eye, risks and diagnosis) and suggested future research directions. Conclusions: The current results laid the foundation of bibliometrics for scholars and identified researchers, scientific journals, countries, keyword clustering, hot topics, and trends in the literature. High-impact-factor journals contain the most keyword-clustering research and open new horizons for research in the pregnancy-related eye disease nursing field, providing research inspiration for investigators in this field. Significance: What is Already Known on this Subject?: Eye disease is a multifactorial disorder. It can occur when ocular surface inflammation and damage are handled improperly or inadequately and may ultimately impair the quality of life and vision of affected patients. Whether and how scholars' research issues are linked to pregnancy-related eye disease is less understood. Therefore, with the help of bibliometric methods, reviews and original papers on pregnancy-related eye disease were categorized and summarized for analysis, and hotspots and trends were analyzed to obtain a comprehensive picture of the characteristics of research in this field. What does this Study Add?: This analysis provides a new review of the keywords that appear most frequently, including the visualization of the research network. Thus, the keywords appearing most frequently in the research literature could open new horizons for research in the field of pregnancy-related eye disease.
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