Clinical relevance of Staphylococcus saccharolyticus detection in human samples: a retrospective cohort study.
Purpose: To characterize the clinical relevance of S. saccharolyticus and to identify criteria to distinguish between infection and contamination. Methods: We retrospectively investigated clinical features of patients with S. saccharolyticus detection between June 2009 and July 2021. Based on six cr...
| Publicado en: | Infection Vol. 53; no. 1; pp. 145 - 154 |
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| Autores principales: | , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Feb2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=183079892&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 183079892 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03008126 NXO jtl: Infection issn: 03008126 maglogo: N pubinfo: dt: Feb2025 vid: 53 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 183079892 178265902 183079892 183079892 10.1007/s15010-024-02334-6 183079892 ppf: 145 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Clinical relevance of Staphylococcus saccharolyticus detection in human samples: a retrospective cohort study. aug: au: Michels, Ricarda Papan, Cihan Boutin, Sébastien Alhussein, Farah Becker, Sören L. Nurjadi, Dennis Last, Katharina affil: https://ror.org/01jdpyv68 Center for Infectious Diseases, Institute of Medical Microbiology and Hygiene, Saarland University, Homburg, Germany sug: subj: Staphylococcal Infections Microbiology Bacterial Contamination Evaluation Bacterial Infections Diagnosis Staphylococcus Analysis Staphylococcal Infections Diagnosis Staphylococcal Infections Drug Therapy Treatment Outcomes Human Retrospective Design Genome Sequence Analysis Logistic Regression Confidence Intervals Descriptive Statistics Length of Stay C-Reactive Protein Blood ab: Purpose: To characterize the clinical relevance of S. saccharolyticus and to identify criteria to distinguish between infection and contamination. Methods: We retrospectively investigated clinical features of patients with S. saccharolyticus detection between June 2009 and July 2021. Based on six criteria, infection was considered likely for patients with a score from 3 to 6 points, infection was considered unlikely for patients with a score from 0 to 2 points. We performed group comparison and logistic regression to identify factors than are associated with likely infection. In addition, whole genome sequencing (WGS) of 22 isolates was performed. Results: Of 93 patients in total, 44 were assigned to the group "infection likely" and 49 to the group "infection unlikely". Multiple regression analysis revealed "maximum body temperature during hospital stay" to have the strongest predictive effect on likely infection (adjusted odds ratio 4.40, 95% confidence interval 2.07–9.23). WGS revealed two different clades. Compared to isolates from clade A, isolates from clade B were more frequently associated with implanted medical devices (3/10 vs. 9/12, p = 0.046) and a shorter time to positivity (TTP) (4.5 vs. 3, p = 0.016). Both clades did neither differ significantly in terms of causing a likely infection (clade A 7/10 vs. clade B 5/12, p = 0.23) nor in median length of hospital stay (28 vs. 15.5 days, p = 0.083) and length of stay at the ICU (21 vs. 3.5 days, p = 0.14). Conclusion: These findings indicate that S. saccharolyticus can cause clinically relevant infections. Differentiation between infection and contamination remains challenging. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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