Management and outcome of cutaneous diphtheria in adolescent refugees in Germany, June 2022 – October 2023.
Objectives: From September 2022 an increase in Corynebacterium diphtheriae (C. diphtheriae) infections was reported in Europe. Our study focuses on 31 adolescent and young adult refugees with cutaneous C. diphtheriae infections detected in Germany. We examined treatment regimens and outcomes to prov...
| Publicado en: | Infection Vol. 53; no. 1; pp. 329 - 338 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Feb2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=183079914&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 183079914 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03008126 NXO jtl: Infection issn: 03008126 maglogo: N pubinfo: dt: Feb2025 vid: 53 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 183079914 179271191 183079914 183079914 10.1007/s15010-024-02374-y 183079914 ppf: 329 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Management and outcome of cutaneous diphtheria in adolescent refugees in Germany, June 2022 – October 2023. aug: au: Zink, Alicia Hofer, Juliana Schneider, Christian Kessler, Franziska Klenze, Hannes Klauwer, Dietrich Maleki, Klaudia Müller, Andreas Goretzki, Sarah Wang, Shubei Kobbe, Robin Ramirez, Andrea Vanegas Bode, Sebastian Janda, Ales Fressle, Roland Remppis, Jonathan Henneke, Philipp Rieg, Siegbert Berger, Anja Sing, Andreas affil: https://ror.org/0245cg223 Division for Paediatric Infectious Diseases and Rheumatology, Department of Paediatrics and Adolescent Medicine, University Medical Centre, Medical Faculty, University of Freiburg, Freiburg, Germany sug: subj: Diphtheria Drug Therapy Diphtheria In Adolescence Refugees Psychosocial Factors Disease Management Treatment Outcomes Human Funding Source Germany Antiinfective Agents, Local Clindamycin Descriptive Statistics Adolescence Treatment Duration Wound Healing Adolescent: 13-18 years ab: Objectives: From September 2022 an increase in Corynebacterium diphtheriae (C. diphtheriae) infections was reported in Europe. Our study focuses on 31 adolescent and young adult refugees with cutaneous C. diphtheriae infections detected in Germany. We examined treatment regimens and outcomes to provide targeted insights into the management of this infection. Methods: We distributed a standardized survey, focused on children and adolescents presenting to paediatric clinics through the German Paediatric Infectious Diseases Society (DGPI) and additional professional contacts in Germany. Data were extracted from routine medical documentation and reported anonymously. Results: A total of 31 individuals with cutaneous C. diphtheriae infection were reported by 9 centres. Two of these showed diphtheria toxin (DT) related systemic symptoms and four exhibited systemic inflammation requiring complex management. The remaining 25 cases, with exclusively cutaneous manifestations, were afebrile. Treatment with topical antiseptics and systemic antibiotics, mainly aminopenicillin/beta-lactamase inhibitors (BLI) (35%) or clindamycin (25%), achieved eradication in all but two cases treated with aminopenicillin/BLI. Treatment duration varied between 5 and 17 days. Conclusions: In refugees presenting with chronic skin wounds, C. diphtheriae should be included into the differential diagnosis. Fever seems to be a valuable marker to differentiate severe cases with potentially DT-mediated sequelae from exclusively cutaneous diphtheria (CD). For afebrile CD, topical antiseptics and oral antibiotic therapy with clindamycin for 7 days, followed by clinical surveillance appears to be a safe treatment regimen. Patients with CD who present with fever or pharyngitis should be thoroughly investigated including blood and pharyngeal swab cultures. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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