Lautropia mirabilis sepsis in immunodeficiency: first report and genomic features.
Purpose: Lautropiamirabilis is a Gram-negative, facultative anaerobic coccus, which has been detected mainly in respiratory sites of immunodeficient patients suffering from HIV or cystic fibrosis. To date, knowledge about the pathogenicity of L. mirabilis is spare due to the small numbers of documen...
| Publicado en: | Infection Vol. 53; no. 1; pp. 457 - 463 |
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| Autores principales: | , , , , , , , , , |
| Formato: | case study pictorial tables/charts Journal Article |
| Publicado: |
Springer Nature
Feb2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=183079921&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 183079921 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03008126 NXO jtl: Infection issn: 03008126 maglogo: N pubinfo: dt: Feb2025 vid: 53 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 183079921 179458236 183079921 183079921 10.1007/s15010-024-02388-6 183079921 ppf: 457 ppct: 6 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Lautropia mirabilis sepsis in immunodeficiency: first report and genomic features. aug: au: Genseke, Svea Berisha, Mirjeta Teerstegen, Aljoscha Meyer, Björn Kaasch, Achim J. Färber, Jacqueline Schalk, Enrico Zautner, Andreas E. Esser, Torben Kahlfuß, Sascha affil: https://ror.org/00ggpsq73 Medical Faculty, Institute of Medical Microbiology and Hospital Hygiene, Otto von Guericke University Magdeburg, Magdeburg, Germany sug: subj: Sepsis Microbiology Common Variable Immunodeficiency Complications Meropenem Therapeutic Use Genomics Adult Female Immunoglobulins Deficiency Immunoglobulins Adverse Effects Periodontitis Complications Sequence Analysis Bacteremia Drug Therapy Funding Source Adult: 19-44 years Female ab: Purpose: Lautropiamirabilis is a Gram-negative, facultative anaerobic coccus, which has been detected mainly in respiratory sites of immunodeficient patients suffering from HIV or cystic fibrosis. To date, knowledge about the pathogenicity of L. mirabilis is spare due to the small numbers of documented cases. Methods: We present a literature review and report the case of a 39-year-old female diagnosed with common variable immunodeficiency (CVID) with IgG and IgA deficiency suffering from a sepsis with L. mirabilis. As no fully closed L. mirabilis genome besides the type strain was available to date, we additionally performed complete genome sequencing of L. mirabilis. Results: The patient was admitted to our hospital with recurrent episodes of fever. Here, we detected L. mirabilis in two different blood cultures. The bacterium was tested susceptible to and treated with meropenem. As the origin of L. mirabilis sepsis, we observed an active periodontitis likely due to impaired IgA levels and mucosal insufficiency as a consequence of CVID. Whole genome sequencing of L. mirabilis revealed several genes important for host cell invasion and intracellular survival of the pathogen. Conclusions: Our case highlights the importance of L. mirabilis in immunocompromised patients also in other compartments than the respiratory tract. pubtype: Academic Journal doctype: case study pictorial tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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