Clinical and economic inpatient burden of respiratory syncytial virus (RSV) infections in children < 2 years of age in Germany, 2014–2019: a retrospective health claims analysis.
Background: Respiratory syncytial virus (RSV) is a common cause for severe lower respiratory tract infections (LRTI) in children < 2 years of age in Germany – though little is known about the clinical and economic burden of RSV in children with and without risk factors per month of life. Methods: In...
| Published in: | Infection Vol. 53; no. 1; pp. 393 - 405 |
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| Main Authors: | , , , , , , , |
| Format: | research tables/charts Journal Article |
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Springer Nature
Feb2025
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=183079923&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 183079923 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03008126 NXO jtl: Infection issn: 03008126 maglogo: N pubinfo: dt: Feb2025 vid: 53 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 183079923 179921669 183079923 183079923 10.1007/s15010-024-02391-x 183079923 ppf: 393 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Clinical and economic inpatient burden of respiratory syncytial virus (RSV) infections in children < 2 years of age in Germany, 2014–2019: a retrospective health claims analysis. aug: au: Lade, Caroline Bayer, Lea Huebbe, Bennet Riedel, Jennifer Melnik, Sima Brestrich, Gordon von Eiff, Christof Tenenbaum, Tobias affil: https://ror.org/00m8w3m39 Pfizer Pharma GmbH, Berlin, Germany sug: subj: Respiratory Syncytial Virus Infections Epidemiology Respiratory Syncytial Virus Infections Mortality Respiratory Syncytial Virus Infections Economics Economic Aspects of Illness Health Resource Utilization Health Expenditures Human Germany Male Female Infant Child, Preschool Retrospective Design Record Review Inpatients Financial Stress Health Care Costs Funding Source Infant: 1-23 months Child, Preschool: 2-5 years Male Female ab: Background: Respiratory syncytial virus (RSV) is a common cause for severe lower respiratory tract infections (LRTI) in children < 2 years of age in Germany – though little is known about the clinical and economic burden of RSV in children with and without risk factors per month of life. Methods: In a retrospective health claims analysis, we identified RSV inpatient cases between 2014 and 2019. We assessed incidence rates, mortality rate, healthcare resource utilization, associated direct costs per case and excess costs for 30, 90 and 365 days after hospital admission matched to a control group. The outcomes are reported separately for the first and second year of life (i.e., for infants and toddlers) and were stratified by month of life, preterm and risk status (i.e., presence of underlying disease: chronic respiratory or cardiac disease, immunosuppression, neurological diseases, diabetes, conditions originating in the perinatal period). Results: RSV-attributable hospital incidence rate was higher in infants (30.25/1,000) than toddlers (14.52/1,000), highest in the first three months of life (44.21/1,000), in infants born preterm (64.76/1,000) or with any underlying disease (54.85/1,000). Mortality rate was also higher for infants (0.08/1,000) than toddlers (0.04/1,000). Mean 30-day excess costs ranged from 2,953 € for infants born full-term at no risk, hospitalized for 5 days, to 6,694 € for infants born extremely premature, hospitalized for 7 days. Conclusion: In Germany, the clinical and economic burden of RSV is substantial, especially in the most vulnerable population, that is, very young infants, those born premature and/or those with an underlying disease. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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