Remnant cholesterol, a potential risk factor of metabolic dysfunction-associated fatty liver disease.
Objectives: This study aimed to explore the association between remnant cholesterol and metabolic dysfunction-associated fatty liver disease (MAFLD) in an adult population in the United States. Methods: Data were collected from the National Health and Nutrition Examination Survey database during 201...
| Publicado en: | Nutrition & Metabolism Vol. 22; no. 1; pp. 1 - 11 |
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| Autores principales: | , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
BioMed Central
2/18/2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=183109882&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 183109882 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 17437075 1CYX jtl: Nutrition & Metabolism issn: 17437075 maglogo: N pubinfo: dt: 2/18/2025 vid: 22 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 183109882 183109882 183109882 10.1186/s12986-025-00898-0 183109882 ppf: 1 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Remnant cholesterol, a potential risk factor of metabolic dysfunction-associated fatty liver disease. aug: au: Hao, Xuanyu Li, Dongyang Huang, Xingyong Wang, Tingting Wu, Peng Shen, Lufan Zhang, Kai Sun, Siyu affil: https://ror.org/04wjghj95 Department of Gastroenterology, Endoscopic Center, Engineering Research Center of Ministry of Education for Minimally Invasive Gastrointestinal Endoscopic Techniques, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, 110004, Shenyang, Liaoning, China sug: subj: Metabolic Diseases Complications Fatty Liver Risk Factors Risk Assessment Cholesterol Analysis Human United States Female Male Adult Questionnaires Surveys Fatty Liver Epidemiology Prevalence Multivariate Analysis Logistic Regression ROC Curve Odds Ratio Confidence Intervals Data Analysis Software Descriptive Statistics Funding Source Adult: 19-44 years Female Male ab: Objectives: This study aimed to explore the association between remnant cholesterol and metabolic dysfunction-associated fatty liver disease (MAFLD) in an adult population in the United States. Methods: Data were collected from the National Health and Nutrition Examination Survey database during 2017–2020. Weighted multivariable logistic regression analyses and receiver operating characteristic (ROC) curves were used to investigate the association between remnant cholesterol and the risk of MAFLD. Subgroup and interaction analyses were performed. To further investigate the possible non-linear relationship between remnant cholesterol and MAFLD, a restricted cubic spline was used. Results: Among the included 3633 participants, the prevalence rate of MAFLD was 34.56%. After full adjustment, higher remnant cholesterol was associated with the risk of MAFLD (odds ratio [OR], 1.04; 95% confidence interval [CI], 1.01–1.06; P = 0.02), and compared with the lowest quartile of remnant cholesterol, the highest quartile of remnant cholesterol was more likely to be associated with MAFLD (OR, 3.70; 95%CI, 2.37,5.76; P < 0.0001). A non-linear relationship between remnant cholesterol and MAFLD was found in the restricted cubic spline regression model, suggesting that the risk of MAFLD initially increased rapidly and then gradually slowed down. Conclusion: Remnant cholesterol was identified as a potential risk factor for MAFLD, and a non-linear relationship between remnant cholesterol and the prevalence of MAFLD was detected. Large-scale, high-quality prospective studies are required to validate these findings. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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