Presynaptic terminal integrity is associated with glucose metabolism in Parkinson's disease.
Objective: To investigate the relationship of synaptic loss with glucose metabolism and dopaminergic transporters in Parkinson's disease (PD) patients. Methods: A total of 16 patients with PD and 11 age-matched healthy controls underwent positron emission tomography (PET) with the tracers [18F]SynVe...
| Publicado en: | European Journal of Nuclear Medicine & Molecular Imaging Vol. 52; no. 4; pp. 1510 - 1520 |
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| Autores principales: | , , , , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Mar2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=183131167&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 183131167 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16197070 NPC jtl: European Journal of Nuclear Medicine & Molecular Imaging issn: 16197070 maglogo: N pubinfo: dt: Mar2025 vid: 52 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 183131167 181006011 10.1007/s00259-024-06993-3 183131167 ppf: 1510 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Presynaptic terminal integrity is associated with glucose metabolism in Parkinson's disease. aug: au: Wang, Weiyi Wang, Yanru Xu, Limin Liu, Xueling Hu, Yuqing Li, Junpeng Huang, Qi Ren, Shuhua Huang, Yiyun Guan, Yihui Li, Yuxin Hua, Fengchun Ye, Qing Xie, Fang affil: https://ror.org/013q1eq08 Department of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, 200040, Shanghai, China sug: ab: Objective: To investigate the relationship of synaptic loss with glucose metabolism and dopaminergic transporters in Parkinson's disease (PD) patients. Methods: A total of 16 patients with PD and 11 age-matched healthy controls underwent positron emission tomography (PET) with the tracers [18F]SynVesT-1, a ligand for the presynaptic terminal marker synaptic vesicle protein 2 A (SV2A), and FDG. PD patients also underwent PET with the dopamine transporter (DAT) ligand [18F]FP-CIT. The difference in synaptic density between PD patients and age-matched normal controls(NCs) was determined in the selected regions of interest, and the correlations of the [18F]SynVesT-1 PET SUVRs with [18F]FP-CIT PET SUVRs and [18F]FDG PET SUVRs were evaluated. Results: Compared with that in the NC group, the synaptic density in the caudate region was significantly lower in the PD group (SUVR: 2.51 ± 0.36 vs. 3.18 ± 0.32, p < 0.001), especially in the pre-commissural caudate and post-commissural caudate (SUVR: 2.42 ± 0.29 vs. 2.63 ± 0.32, p < 0.01; 0.76 ± 0.31 vs. 0.97 ± 0.33, p < 0.001). A reduced synaptic density was significantly correlated with DAT (r = 0.61, p < 0.001) and glucose metabolism (r = 0.73, p < 0.001) in the post-commissural caudate. In the post-commissural regions of the caudate, there was a partial mediating effect of synaptic density on the relationship between glucose metabolism and DAT availability (indirect effect: β4 = 0.039, p = 0.024). Conclusion: [18F]SynVesT-1 binds specifically to SV2A, reflecting synaptic density, and there is a positive correlation metabolic pattern related to the changes reflected by [18F]SynVesT-1 and [18F]FDG. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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