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Anti‐microtubular activity of total alkaloids and aqueous extract of Detarium microcarpum a medicinal plant harvested in Mali: Anti‐microtubular activity of total alkaloids and aqueous extract of Detarium microcarpum a medicinal plant harvested in Mali: Dembele et al

Detarium microcarpum, is a species confined to drier regions of west and central Africa used to treat various diseases including cancer. Phytochemical screening revealed the presence of secondary metabolites (alkaloids) The aim of this work is to study the effect of total aqueous extracts and alkalo...

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Published in:Protoplasma Vol. 262; no. 2; pp. 415 - 431
Main Authors: Dembele, Niaboula, Somboro, Aimé Ainin, Traore, Nah, Badiaga, Mamadou, Cisse, Salimatou, Cisse, Mody, Nick, Peter
Format: Journal Article
Published: Springer Nature Mar2025
Online Access:View this record in EBSCOhost
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      dt: Mar2025
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      pub: Springer Nature
      place: New York, New York
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        180692395
        10.1007/s00709-024-02003-3
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        atl: Anti‐microtubular activity of total alkaloids and aqueous extract of Detarium microcarpum a medicinal plant harvested in Mali: Anti‐microtubular activity of total alkaloids and aqueous extract of Detarium microcarpum a medicinal plant harvested in Mali: Dembele et al
      aug:
        au:
          Dembele, Niaboula
          Somboro, Aimé Ainin
          Traore, Nah
          Badiaga, Mamadou
          Cisse, Salimatou
          Cisse, Mody
          Nick, Peter
        affil: https://ror.org/023rbaw78 Institute of Applied Sciences, USTTB, Bamako, Mali
      sug:
      ab: Detarium microcarpum, is a species confined to drier regions of west and central Africa used to treat various diseases including cancer. Phytochemical screening revealed the presence of secondary metabolites (alkaloids) The aim of this work is to study the effect of total aqueous extracts and alkaloid fractions from D. microcarpum leaves, bark and roots on Nicotiana tabacum L. cv. 'Bright Yellow 2' (BY-2) tobacco cell line GFP-TuA3 expressing a N-terminal fusion of GFP. The plant was harvested in two different regions of Mali with a contrasting climate. The effects of the extracts on the microtubules was followed by spinning disc confocal microscopy. We showed that the anti-microtubular effect of the extracts is dose-dependent, depends of the sampling site and the part of the plant used. Total alkaloids extracted of D. microcarpum bark have more effect on microtubules than leaf and root. The bioactivity‐guided fractionation should be used to screen out the biologically active compounds of the total alkaloid extracts of the bark of D. microcarpum.
      pubtype: Academic Journal
      doctype: Journal Article
      ougenre: Article
    language: English
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