Brain compensatory activation during Stroop task in patients with mild cognitive impairment: a functional near-infrared spectroscopy study.
Purpose: This study investigated the disparities in brain activation patterns during the Stroop task among individuals with mild cognitive impairment (MCI) and those without any cognitive impairments (healthy controls, HCs) using functional near-infrared spectroscopy (fNIRS). Methods: We analyzed th...
| Publicado en: | Frontiers in Aging Neuroscience pp. 1 - 13 |
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| Autores principales: | , , , , , , , |
| Formato: | equations & formulas pictorial research tables/charts Journal Article |
| Publicado: |
Frontiers Media S.A.
2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=183202410&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 183202410 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16634365 BG2U jtl: Frontiers in Aging Neuroscience issn: 16634365 maglogo: N pubinfo: dt: 2025 pid: 40038 pub: Frontiers Media S.A. artinfo: ui: 183202410 183202410 183202410 10.3389/fnagi.2025.1470747 183202410 ppf: 1 ppct: 12 formats: tig: atl: Brain compensatory activation during Stroop task in patients with mild cognitive impairment: a functional near-infrared spectroscopy study. aug: au: Fan, Chenyu Li, Hanfei Chen, Ke Yang, Guohui Xie, Hongyu Li, Haozheng Wu, Yi Li, Meng affil: Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, China sug: subj: Brain Physiology Mild Cognitive Impairment Neuropsychological Tests Methods Spectroscopy, Near-Infrared Task Performance and Analysis Human Funding Source Male Female Middle Age Aged Aged, 80 and Over Correlational Studies Descriptive Statistics Comparative Studies Data Analysis Software T-Tests Chi Square Test Pearson's Correlation Coefficient Clinical Assessment Tools Prefrontal Cortex Parietal Lobe Oxygenation Executive Function Community Health Centers Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Male Female ab: Purpose: This study investigated the disparities in brain activation patterns during the Stroop task among individuals with mild cognitive impairment (MCI) and those without any cognitive impairments (healthy controls, HCs) using functional near-infrared spectroscopy (fNIRS). Methods: We analyzed the cortical activation patterns of 73 patients with MCI and 63 HC individuals as they completed the Stroop task, employing fNIRS. The regions of interest (ROIs) included the dorsal prefrontal cortex (dPFC), ventrolateral prefrontal cortex (VLPFC), and parietal lobe (PL). The Stroop task is divided into early stage (0–15 s) and late stage (15–30 s). We also measured participants' behavior during the Stroop task, analyzed variations in cortical activation intensity at different experiment stages, and performed correlation analysis between Montreal Cognitive Assessment (MoCA) scores, Stroop performance, and oxygenation levels. Results: Our analysis revealed that individuals with MCI and HC demonstrated elevated cortical activation in the dPFC, VLPFC, and PL areas while performing the Stroop task (q < 0.05, FDR-corrected). The MCI group displayed longer response latencies compared to the HC group while demonstrating comparable accuracy performance across both congruent and incongruent Stroop trials. The MCI group showed compensatory activation in the VLPFC, and PL regions compared to the HC group during the late stage of the Stroop task (q < 0.05, FDR-corrected). Correlational analysis revealed a negative association between MoCA scores and oxygenation levels in the dPFC, VLPFC, and PL regions during the late stage of the Stroop task (p < 0.05). However, no correlation was found with behavioral performance. Conclusion: Mild cognitive impairment patients demonstrated effective compensation for their cognitive impairments at a partial behavioral level by engaging compensatory activation in the prefrontal, and parietal regions while performing the Stroop task. pubtype: Academic Journal doctype: equations & formulas pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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