Preterm Birth in African American Women: A Multi-Omic Pilot Study in Early Pregnancy.
Preterm birth (PTB; <37 weeks completed gestation) is a devastating problem affecting over 13 million live births worldwide. In the U.S., African Americans experience significantly higher rates of PTB compared to non-Hispanic Whites. PTB disparities have been linked to social determinants of health...
| Publicado en: | Biological Research for Nursing Vol. 27; no. 2; pp. 205 - 216 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Sage Publications Inc.
Apr2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=183272814&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 183272814 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10998004 5WE jtl: Biological Research for Nursing issn: 10998004 maglogo: Y pubinfo: dt: Apr2025 vid: 27 iid: 2 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 183272814 180448160 183272814 183272814 10.1177/10998004241275049 183272814 ppf: 205 ppct: 11 formats: tig: atl: Preterm Birth in African American Women: A Multi-Omic Pilot Study in Early Pregnancy. aug: au: Nowak, Alexandra L. Saadat, Nadia Sun, Jiao Forsman, Anna M. Liang, Xiaoyu Joyce, Cara Woo, Jennifer Engeland, Christopher G. Misra, Dawn P. Giurgescu, Carmen Zhang, Wei Anderson, Cindy M. affil: Marcella Niehoff School of Nursing, 550858 Loyola University at Chicago, Maywood, IL, USA sug: subj: African Americans Childbirth, Premature DNA Methylation RNA, Messenger Pregnancy Trimester, First Pregnancy Trimester, Second Human Female Adolescence Adult Middle Age Pilot Studies Multiomics Pregnancy Gene Expression Post Hoc Analysis Biological Markers Case Control Studies Ohio Questionnaires Funding Source Adolescent: 13-18 years Adult: 19-44 years Middle Aged: 45-64 years Female ab: Preterm birth (PTB; <37 weeks completed gestation) is a devastating problem affecting over 13 million live births worldwide. In the U.S., African Americans experience significantly higher rates of PTB compared to non-Hispanic Whites. PTB disparities have been linked to social determinants of health (e.g., socioeconomic status, discrimination). However, the biological underpinnings related to these associations are unclear. DNA methylation (DNAm) is subject to environmental influences, and DNAm modifications are known to affect gene expression. Using a multi-omic approach, we examined differences in combined DNA methylation (DNAm) and messenger RNA (mRNA) transcriptomic data from 20 pregnant African American women (12 PTB; 8 term birth) early in pregnancy (8–18 weeks gestation). We found that the HLA- DQB2 gene was both differentially methylated (cg12296550; p =.02) and differentially expressed (p =.014; log2FC = 2.5) between women with PTB and term birth. Gene expression analysis showed HLA- DQB2 and HLA- DRB4 (p =.028; log2FC = −3.6) were the two most highly expressed genes. HLA-DQB2 expressed higher in PTB and HLA- DRB4 expressed higher in term birth. However, no genes remained significant (p <.05) after Bonferroni correction. HLA- DRB4 and AKR1C1 were identified as a potential biomarkers in dimensionality reduction models and are also important to immune function and allogenic breakdown. Altered gene expression may lead to inflammatory imbalances or allogenic intolerance resulting in PTB. This study provides proof-of-concept evidence for the feasibility and importance of future multi-omics studies with larger populations to further explore the genes and pathways identified here. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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