| Sumario: | Traditional and complementary medicine (T&CM) plays a significant role in healthcare practices among healthcare professionals and oncology patients in Mexico, reflecting its cultural importance. This study aimed to analyze the prevalence, frequency, and factors associated with T&CM use in these two groups, highlighting the differences in practices and perceptions. A total of 382 individuals participated, including 152 healthcare professionals and 230 oncology patients. The findings revealed that while T&CM use was similarly prevalent among healthcare professionals (85.7%) and oncology patients (90.8%), frequent use (≥2 times per week) was significantly higher among patients (46.3%) compared to healthcare professionals (19.1%, p < 0.001). Healthcare professionals showed a preference for non-conventional nutritional interventions (32.5%) and yoga (14.6%) while oncology patients favored plant-based remedies (73.6%) and the consumption of exotic animals and venoms (4.8%). Females were more likely to use T&CM across both groups, with a stronger association among healthcare professionals (AdOR 3.695, 95% CI 1.8–7.4). Oncology patients were less likely to understand T&CM concepts and were more commonly associated with lower socioeconomic status and educational attainment. These findings underscore the importance of considering cultural and demographic factors when integrating T&CM into conventional medical care, especially in regions where T&CM remains widely practiced and trusted.
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