Development and Characterization of Cumin Oil-Nanoemulsions and its Enhanced Antibacterial Activity against Some Bacteria.
Background & Objective: Antibiotic resistance has become a global problem. This study aimed to develop and evaluate nanoemulsions' capacity to improve Cuminum cyminum's antibacterial activity essential oil as an appropriate approach to prevent microbial resistance. Materials & Methods: Gas chromatog...
| Publicado en: | Journal of Advances in Medical & Biomedical Research Vol. 32; no. 155; pp. 427 - 438 |
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| Autores principales: | , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Zanjan University of Medical Sciences & Health Services
Nov/Dec2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=183301586&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 183301586 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 26766264 N5MJ jtl: Journal of Advances in Medical & Biomedical Research issn: 26766264 maglogo: N pubinfo: dt: Nov/Dec2024 vid: 32 iid: 155 pid: 65276 pub: Zanjan University of Medical Sciences & Health Services artinfo: ui: 183301586 183301586 183301586 10.30699/jambr.32.155.427 183301586 ppf: 427 ppct: 11 formats: fmt: @attributes: type: P tig: atl: Development and Characterization of Cumin Oil-Nanoemulsions and its Enhanced Antibacterial Activity against Some Bacteria. aug: au: Khani, Fatemeh Hosseinali Yazdinezhad, Alireza Sadighian, Somayeh Mohseni, Mehran affil: Department of Food and Drug Control, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran. sug: subj: Plants Analysis Essential Oils Analysis Nanoparticle Drug Delivery System Drug Resistance, Microbial Antibiotics Seeds Human Funding Source Descriptive Statistics Gas Chromatography-Mass Spectrometry Pseudomonas Klebsiella Infections In Vitro Studies Post Hoc Analysis ab: Background & Objective: Antibiotic resistance has become a global problem. This study aimed to develop and evaluate nanoemulsions' capacity to improve Cuminum cyminum's antibacterial activity essential oil as an appropriate approach to prevent microbial resistance. Materials & Methods: Gas chromatography-mass spectrometry was used to determine the main constituent of C. cyminum essential oil. FT-IR was used to investigate the functional groups of chemical composition. A nanoemulsion was generated using high-shear homogenization, followed by several physicochemical characterizations. The antibacterial activity of essential oil in both pure and nanoemulsion forms against important food-borne pathogens, and drug-resistant bacteria was determined by measuring the Minimum Inhibitory Concentration (MIC) and the Minimum Bactericidal Concentration (MBC). Results: Cumin aldehyde with 20.08%w/v is the main constituent of essential oil. The prepared nanoemulsions had an average size of 72 nm, particle distribution of 0.234, and zeta potential of 26 mV. Nanoemulsion formulations of essential oils are more effective compared to pure ones. Klebsiella pneumonia and Pseudomonas aeruginosa have the highest and the lowest antimicrobial effects of essential oil among all studied bacteria, respectively. In contrast, in resistant samples, the major and minor effects were contributed to Methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus, respectively. Conclusion: Cumin oil-nanoemulsion had an acceptable function against antibiotic-resistant bacteria. It is advisable to combine this formulation with synthetic antibiotics in order to reduce bacterial resistance and serve as a preservative in the pharmaceutical and food industries. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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