Bridging the Clinical-Computational Transparency Gap in Digital Pathology.

Context.--Computational pathology combines clinical pathology with computational analysis, aiming to enhance diagnostic capabilities and improve clinical productivity. However, communication barriers between pathologists and developers often hinder the full realization of this potential. Objective.-...

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Publicado en:Archives of Pathology & Laboratory Medicine Vol. 149; no. 3; pp. 276 - 288
Autores principales: Qiangqiang Gu, Patel, Ankush, Hanna, Matthew G., Lennerz, Jochen K., Garcia, Chris, Zarella, Mark, McClintock, David, Hart, Steven N.
Formato: pictorial review tables/charts Journal Article
Publicado: College of American Pathologists Mar2025
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Mar2025
      vid: 149
      iid: 3
      pid: 2550
      pub: College of American Pathologists
      place: Northfield, Illinois
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        10.5858/arpa.2023-0250-RA
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        atl: Bridging the Clinical-Computational Transparency Gap in Digital Pathology.
      aug:
        au:
          Qiangqiang Gu
          Patel, Ankush
          Hanna, Matthew G.
          Lennerz, Jochen K.
          Garcia, Chris
          Zarella, Mark
          McClintock, David
          Hart, Steven N.
        affil: Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota
      sug:
        subj:
          Digital Imaging
          Image Processing, Computer Assisted
          Pathology, Clinical
          Diagnosis, Computer Assisted
          Pathologists
          Algorithms
          Pathology
          Professional Practice
          Machine Learning
          Microscopy, Virtual
          Patient Care
      ab: Context.--Computational pathology combines clinical pathology with computational analysis, aiming to enhance diagnostic capabilities and improve clinical productivity. However, communication barriers between pathologists and developers often hinder the full realization of this potential. Objective.--To propose a standardized framework that improves mutual understanding of clinical objectives and computational methodologies. The goal is to enhance the development and application of computer-aided diagnostic (CAD) tools. Design.--This article suggests pivotal roles for pathologists and computer scientists in the CAD development process. It calls for increased understanding of computational terminologies, processes, and limitations among pathologists. Similarly, it argues that computer scientists should better comprehend the true use cases of the developed algorithms to avoid clinically meaningless metrics. Results.--CAD tools improve pathology practice significantly. Some tools have even received US Food and Drug Administration approval. However, improved understanding of machine learning models among pathologists is essential to prevent misuse and misinterpretation. There is also a need for a more accurate representation of the algorithms' performance compared to that of pathologists. Conclusions.--A comprehensive understanding of computational and clinical paradigms is crucial for overcoming the translational gap in computational pathology. This mutual comprehension will improve patient care through more accurate and efficient disease diagnosis.
      pubtype: Academic Journal
      doctype:
        pictorial
        review
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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