Associations between brain network, puberty, and behaviors in boys with Klinefelter syndrome.
Background: Klinefelter syndrome (KS), also referred to as XXY syndrome, is a significant but inadequately studied risk factor for neuropsychiatric disability. Whether alterations in functional brain connectivity or pubertal delays are associated with aberrant cognitive-behavioral outcomes in indivi...
| Publicado en: | European Child & Adolescent Psychiatry Vol. 34; no. 2; pp. 585 - 598 |
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| Autores principales: | , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Feb2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=183352864&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 183352864 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10188827 EJ3 jtl: European Child & Adolescent Psychiatry issn: 10188827 maglogo: N pubinfo: dt: Feb2025 vid: 34 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 183352864 177988671 183352864 183352864 10.1007/s00787-024-02501-y 183352864 ppf: 585 ppct: 13 formats: fmt: @attributes: type: P tig: atl: Associations between brain network, puberty, and behaviors in boys with Klinefelter syndrome. aug: au: Li, Rihui Foland-Ross, Lara C. Jordan, Tracy Marzelli, Matthew J. Ross, Judith L. Reiss, Allan L. affil: https://ror.org/01r4q9n85 Center for Cognitive and Brain Sciences, Institute of Collaborative Innovation, University of Macau, Taipa, Macao S.A.R., China sug: subj: Klinefelter's Syndrome In Adolescence Puberty Men Functional Connectivity Evaluation Adolescent Behavior Evaluation Cognition Funding Source Human Male Adolescence Child Nonexperimental Studies Descriptive Statistics Testosterone Magnetic Resonance Imaging Machine Learning Verbal Behavior Mediation Analysis Adolescent: 13-18 years Child: 6-12 years Male ab: Background: Klinefelter syndrome (KS), also referred to as XXY syndrome, is a significant but inadequately studied risk factor for neuropsychiatric disability. Whether alterations in functional brain connectivity or pubertal delays are associated with aberrant cognitive-behavioral outcomes in individuals with KS is largely unknown. In this observational study, we investigated KS-related alterations in the resting-state brain network, testosterone level, and cognitive-behavioral impairment in adolescents with Klinefelter syndrome. Methods: We recruited 46 boys with KS, ages 8 to 17 years, and 51 age-matched typically developing (TD) boys. All participants underwent resting-state functional magnetic resonance imaging scans, pubertal, and cognitive-behavioral assessments. Resting-state functional connectivity and regional brain activity of the participants were assessed. Results: We found widespread alterations in global functional connectivity among the inferior frontal gyrus, temporal-parietal area, and hippocampus in boys with KS. Aberrant regional activities, including enhanced fALFF in the motor area and reduced ReHo in the caudate, were also found in the KS group compared to the TD children. Further, using machine learning methods, brain network alterations in these regions accurately differentiated boys with KS from TD controls. Finally, we showed that the alterations of brain network properties not only effectively predict cognitive-behavioral impairment in boys with KS, but also appear to mediate the association between total testosterone level and language ability, a cognitive domain at particular risk for dysfunction in this condition. Conclusion: Our results offer an informatic neurobiological foundation for understanding cognitive-behavioral impairments in individuals with KS and contribute to our understanding of the interplay between pubertal status, brain function, and cognitive-behavioral outcome in this population. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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