Association between twin status with cognitive, behavioral development and brain structure in early adolescence: a retrospective cohort analysis based on the Adolescent Brain Cognitive Development Study.
Twin births are related with maternal and fetal adverse outcomes. Little was known about the comparability of the cognitive, behavioral development and brain structure between twins and singletons in early adolescence. This retrospective cohort study was based on data from the United States populati...
| Publicado en: | European Child & Adolescent Psychiatry Vol. 34; no. 2; pp. 695 - 708 |
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| Autores principales: | , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Feb2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=183352876&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 183352876 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10188827 EJ3 jtl: European Child & Adolescent Psychiatry issn: 10188827 maglogo: N pubinfo: dt: Feb2025 vid: 34 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 183352876 178659202 183352876 183352876 10.1007/s00787-024-02515-6 183352876 ppf: 695 ppct: 13 formats: fmt: @attributes: type: P tig: atl: Association between twin status with cognitive, behavioral development and brain structure in early adolescence: a retrospective cohort analysis based on the Adolescent Brain Cognitive Development Study. aug: au: Zhou, Qiongjie Zhao, Xingzhong Chen, Jingqi Xu, Jinghui Yang, Anyi Xiong, Yu Yin, Xuan Zhao, Xing-Ming Li, Xiaotian affil: https://ror.org/04rhdtb47 Obstetrics and Gynecology Hospital of Fudan University, 200023, Shanghai, China sug: subj: Adolescent Development Twins Psychosocial Factors Cognition Adolescent Behavior Brain Anatomy and Histology Neuroradiography Neurodevelopment Human Funding Source Male Female Child Adolescence Retrospective Design Record Review Prospective Studies Stratified Random Sample Descriptive Statistics Child: 6-12 years Adolescent: 13-18 years Male Female ab: Twin births are related with maternal and fetal adverse outcomes. Little was known about the comparability of the cognitive, behavioral development and brain structure between twins and singletons in early adolescence. This retrospective cohort study was based on data from the United States population-based, prospective, longitudinal observational Adolescent Brain Cognitive Development study. Children with complete twin status information were enrolled, and the exposure variable was twin status. Primary outcomes were cognitive, behavioral development and brain structure in early adolescence. Cognitive and behavioral outcomes were assessed by using the NIH Toolbox and Child Behavioral Checklist, respectively. Brain structure was evaluated by the cortical thickness, area, and volume extracted from the magnetic resonance imaging (MRI) data. Subgroup analyses were conducted by prematurity, birth weight, with sibling, genetic profiles, and twin types (zygosity). From 1st September 2016 to 15th November 2018, 11545 children (9477 singletons and 2068 twins) aged 9–10 years were enrolled. Twins showed mildly lower cognitive performance (|t|> 5.104, P-values < 0.001, False Discovery Rate [FDR] < 0.001), better behavioral outcome (|t|> 2.441, P-values < 0.015, FDR < 0.042), such as lower scores for multiple psychiatric disorders and behavioral issues, and smaller cortical volume (t = − 3.854, P-values < 0.001, FDR < 0.001) and cortical area (t = − 3.872, P-values < 0.001, FDR < 0.001). The observed differences still held when stratified for prematurity, birth weight, presence of siblings, genetic profiles, and twin types (zygosity). Furthermore, analyses on the two-year follow-up data showed consistent results with baseline data. Twin status is associated with lower cognitive and better behavioral development in early adolescence accompanied by altered brain structure. Clinicians should be aware of the possible difference when generalizing results from adolescent twin samples to singletons. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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