| Sumario: | Introduction: Due to the chronic nature of type 2 diabetes mellitus (T2DM) and its potential to induce stress and depression, exploring interventions like cognitive self-compassion training to improve mental well-being in this population is crucial. This study aimed to determine the effectiveness of cognitive selfcompassion training on perceived stress and depression in patients with T2DM. Materials & Methods: The present study was quasi-experimental with a pretest-posttest design and a control group. The statistical population of this study included all patients with T2DM employed in the education sector of Mashhad in 2023. Thus, a sample of 24 (12 per group) was selected using the convenience sampling method and considering the study's inclusion criteria and were randomly assigned to two experimental and control groups. The participants completed the Perceived Stress and Depression Beck questionnaires in the pretest and posttest stages, and the experimental group underwent cognitive self-compassion training for ten 90-minute sessions. Data analysis was performed using analysis of covariance. Statistical significance was set at the level of 0.05. Results: The mean age of all participants was 34.91 (SD = 4.61) years. No significant differences were observed between the experimental and control groups prior to the intervention. However, the findings indicated a significant reduction in both perceived stress and depression scores in the post-intervention period for the cognitive self-compassion training group compared to the control group (P<0.001). Conclusion: Cognitive self-compassion training effectively reduced perceived stress and depression in patients with T2DM, suggesting it as a valuable tool for improving psychological well-being and overall quality of life.
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